Dihydroeponemycin

Dihydroeponemycin, an analogue of the antitumor and antiangiogenic natural product eponemycin, selectively targets the 20S proteasome. Dihydroeponemycin covalently modifies a subset of catalytic proteasomal subunits, binding preferentially to the IFN-gamma-inducible subunits LMP2 and LMP7. Dihydroeponemycin-mediated proteasome inhibition induces a spindle-like cellular morphological change and apoptosis.

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  • CAS No.: 126463-64-7
  • 화학식: C20H36N2O6
  • 분자량:400.51
  • 보관:

    Please store the product under the recommended conditions in the Certificate of Analysis.

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