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Cat. No.: HY-159768A

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DOTAGA.Glu.(FAPi)2

DOTAGA.Glu.(FAPi) 2 is a FAPI homodimer in which a central glutamic acid (Glu) linker connects FAPI and a chelator. Radiolabeled with gallium-⁶⁸, lutetium-¹⁷⁷ or terbium-¹⁶¹, DOTAGA.Glu.(FAPi) 2 is applicable to FAP-positive cancer PET imaging studies. DOTAGA.Glu.(FAPi) 2 is suitable for research related to prostate adenocarcinoma and recurrent glioblastoma multiforme.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2882922-68-9
화학식: C₆₆H₈₁F₄N₁₅O₁₇
분자량:1432.43

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

DOTAGA.Glu.(FAPi)2 Chemical Structure

CAS No.: 2882922-68-9

Amount: USD 0.00

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Use of MCE Products

One-Stop Platform：From Independent R&D to Pilot-Scale Production

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Radionuclide-Drug Conjugates (RDCs) Isoforms :

In Vitro

^68/natGa-DOTAGA.Glu.(FAPi)2 and ^177/natLu-DOTAGA.Glu.(FAPi)2 (0.1-10 nM) bind to FAP⁺ CAFs with high affinity, with K_d values of 0.8 nM and 0.7 nM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

In Vivo

[177Lu]LuDOTAGA.Glu.(FAPi)2 (600 pmol; intravenous injection) exhibits slightly longer initial and terminal half-lives than [¹⁷⁷Lu]Lu-DO3A.Glu.(FAPI)2 in healthy nude mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2882922-68-9
분자량 1432.43
화학식 C₆₆H₈₁F₄N₁₅O₁₇
SMILES

O=C(N1[C@@H](CC(F)(C1)F)C#N)CNC(C2=CC=NC3=C2C=C(OCCCCNC([C@H](CCC(NCCCCOC4=CC5=C(N=CC=C5C(NCC(N6[C@@H](CC(F)(C6)F)C#N)=O)=O)C=C4)=O)NC(CCC(N7CCN(CCN(CCN(CC7)CC(O)=O)CC(O)=O)CC(O)=O)C(O)=O)=O)=O)C=C3)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bilinska A, et al. Preclinical evaluation of DOTAGA.Glu.(FAPI)₂ and DO3A.Glu.(FAPI)₂ as theranostics with human dosimetry extrapolation to lutetium-177 and terbium-161 analogs. Eur J Nucl Med Mol Imaging. 2026;53(3):1887-1901. [Content Brief]

[2]. Ballal S, et al. [¹⁷⁷Lu]Lu-DOTAGA.Glu.(FAPi)₂ Radionuclide Therapy: a New Treatment Option for Patients with Glioblastoma Multiforme. Nucl Med Mol Imaging. 2024;58(1):32-34. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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