ELA-11(human)
Based on 1 Customer Validation
ELA-11(human), a peptide, is a full agonist of human apelin receptor, with a pKi of 7.85. ELA-11(human) completely inhibits Forskolin-induced cAMP production and stimulates β-arrestin recruitment.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity : 99.54%
- CAS No.: 1784687-32-6
- 화학식: C58H90N16O13S2
- 분자량:1283.56
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보관:
Sealed storage, away from moisture and light, under nitrogen.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Biological Activity
제품 설명
IC50 & Target
pKi: 7.85 (apelin receptor)[1]
In Vitro
ELA-11(human) (1 pM-100 nM) completely inhibits Forskolin-induced cAMP production in a concentration-dependent manner[1].
ELA-11(human) (1 pM-1 μM) stimulates β-arrestin recruitment in a concentration-dependent manner with subnanomolar potencies[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1784687-32-6
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Appearance Solid
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분자량 1283.56
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화학식 C58H90N16O13S2
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Color White to off-white
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Sequence
Cys-Met-Pro-Leu-His-Ser-Arg-Val-Pro-Phe-Pro
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Sequence Shortening
CMPLHSRVPFP
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Sealed storage, away from moisture and light, under nitrogen
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
용액&용해도
In Vitro:
H2O : 100 mg/mL (77.91 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Yang P, et, al. Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension. Circulation. 2017 Mar 21;135(12):1160-1173. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.7791 mL | 3.8954 mL | 7.7908 mL | 19.4771 mL |
| 5 mM | 0.1558 mL | 0.7791 mL | 1.5582 mL | 3.8954 mL | |
| 10 mM | 0.0779 mL | 0.3895 mL | 0.7791 mL | 1.9477 mL | |
| 15 mM | 0.0519 mL | 0.2597 mL | 0.5194 mL | 1.2985 mL | |
| 20 mM | 0.0390 mL | 0.1948 mL | 0.3895 mL | 0.9739 mL | |
| 25 mM | 0.0312 mL | 0.1558 mL | 0.3116 mL | 0.7791 mL | |
| 30 mM | 0.0260 mL | 0.1298 mL | 0.2597 mL | 0.6492 mL | |
| 40 mM | 0.0195 mL | 0.0974 mL | 0.1948 mL | 0.4869 mL | |
| 50 mM | 0.0156 mL | 0.0779 mL | 0.1558 mL | 0.3895 mL | |
| 60 mM | 0.0130 mL | 0.0649 mL | 0.1298 mL | 0.3246 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
ELA-11(human) Related Classifications
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