Fandosentan potassium
Fandosentan potassium is a potent endothelin A receptor (ETAR) antagonist. Fandosentan potassium inhibits CYP2C9 and CYP3A4 activities with IC50 values of 39.6 and 21.6 μM, respectively. Fandosentan potassium reverses the hypoxic pulmonary vasoconstriction in the perinatal lamb. Fandosentan potassium can be used for pulmonary hypertension research[1][2].
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 221246-12-4
- 화학식: C25H17F3KNO6S
- 분자량:555.56
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
IC50 & Target
[2]|
CYP3A4 21.6 μM (IC50) |
CYP2C9 39.6 μM (IC50) |
Chemical Information
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CAS No. 221246-12-4
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분자량 555.56
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화학식 C25H17F3KNO6S
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SMILES
O=C(C(N1C2=C(C=CC=C2)C(F)(F)F)=C(C3=CC4=C(OCO4)C(CC)=C3)C5=CC=CC=C5S1(=O)=O)O[K]
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Sahi J, et al. Metabolism and transporter-mediated drug-drug interactions of the endothelin-A receptor antagonist CI-1034. Chem Biol Interact. 2006 Feb 1;159(2):156-68. [Content Brief]
[2]. Coe Y, et al. The endothelin A receptor antagonists PD 156707 (CI-1020) and PD 180988 (CI-1034) reverse the hypoxic pulmonary vasoconstriction in the perinatal lamb. J Pharmacol Exp Ther. 2002 Aug;302(2):672-80. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Fandosentan potassium Related Classifications
HY-105408A Related Classifications
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