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Cat. No.: HY-163405

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Galectin-3-IN-3

Galectin-3-IN-3 (Compound 4) is an orally active and selective inhibitor of Gal-3, with IC₅₀ values of 11 nM and 84 nM against mGal-3 and hGal-3 respectively.

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CAS No.: 2491661-50-6
화학식: C₂₅H₂₂ClF₂N₇O₄S
분자량:590.00

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Galectin-3-IN-3 Chemical Structure

CAS No.: 2491661-50-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Galectin-3-IN-3 (Compound 4) is an orally active and selective inhibitor of Gal-3, with IC₅₀ values of 11 nM and 84 nM against mGal-3 and hGal-3 respectively^[1].

IC₅₀ & Target

hGal-3

11 nM (IC₅₀)

mGal-3

84 nM (IC₅₀)

hGal-1

2720 nM (IC₅₀)

hGal-9

3530 nM (IC₅₀)

All Galectin Isoforms :

In Vivo

Galectin-3-IN-3 (2 mg/kg; i.v.; single dose) exhibits low clearance rate (CL=8 mL/min/kg), high volume of distribution (V_ss=1.8 L/kg), and good oral bioavailability (F=40%) in mice plasma^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2491661-50-6
분자량 590.00
화학식 C₂₅H₂₂ClF₂N₇O₄S
SMILES

CO[C@H]1[C@@H](O[C@@H]([C@@H]([C@@H]1N2C=C(N=N2)C3=C(C(F)=C(C=C3)Cl)F)O)CO)C4=NC(C)=NN4C5=CC6=C(N=CS6)C=C5
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Liu C, et al. Identification of benzothiazole derived monosaccharides as potent, selective, and orally bioavailable inhibitors of human and mouse galectin-3; a rare example of using a S···O binding interaction for drug design. Bioorg Med Chem. 2024;101:117638. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
Chemical Information
순도&문서
References

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Galectin-3-IN-3

All Galectin Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Galectin-3-IN-3 Related Classifications

HY-163405 Related Classifications