Ms4a1 - membrane-spanning 4-domains, subfamily A, member 1 Gene

Also Known as Cd20; Ly-44; Ms4a2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12482

About Ms4a1

Chromosome 19: 11,227,039-11,243,605 reverse strand.GRCm39:CM001012.3

This gene has 3 transcripts (splice variants), 280 orthologues, 21 paralogues and is associated with 4 phenotypes. Biased expression in spleen adult (RPKM 13.9), mammary gland adult (RPKM 3.4) and 2 other tissues.

Summary

Predicted to enable epidermal growth factor receptor binding activity; identical protein binding activity; and immunoglobulin binding activity. Involved in calcium ion import into cytosol. Acts upstream of or within response to bacterium. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; liver and biliary system; and reproductive system. Human ortholog(s) of this gene implicated in common variable immunodeficiency. Orthologous to human MS4A1 (membrane spanning 4-domains A1). [provided by Alliance of Genome Resources, Apr 2022]

Ms4a1 Products (1)

mRNA Protein Name
NM_007641.6 NP_031667.1 B-lymphocyte antigen CD20

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in positive regulation of calcium ion import across plasma membrane IDA
IDA: Inferred from direct assay
14688067 MGI
acts upstream of or within response to bacterium IEP
IEP: Inferred from expression pattern
23012479 MGI
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
19723499 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ms4a1 Protein Structure

CD20

CD20: pfam04103 (43 - 209)

  • 0
  • 100
  • 200
  • 291 a.a.
Protein Preferred Names Protein Names

B-lymphocyte antigen CD20

  • B-cell differentiation antigen Ly-44

  • CD20 antigen

  • lymphocyte antigen 44

  • membrane-spanning 4-domains, subfamily A, member 2

Recombinant Ms4a1 Proteins

Cat. No. 상품명 Accession Purity
HY-P71758 CD20/MS4A1 Protein, Mouse (P.pastoris, His) P19437 (V111-P291) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (3)
Cat. No. 상품명 효과
Purity Phase
HY-P990649 PF-5212374 Inhibitor 97.9% Phase 2
HY-P99308 Ocaratuzumab Inhibitor 95.00% Phase 1
HY-P991671 Anafiltamig Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS08696 MS4A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08697 Ms4a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08698 Ms4a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18183 Ms4a2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24657 Ms4a2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (4)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-P990054 Eramkafusp Alfa / Unkown
HY-P992104 Blidarvetug Inhibitor / Unkown
HY-P992144 Zareprumig Inhibitor 95.34% Unkown
HY-P991546 MEDI-552 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ms4a1 NCBI NCBI:931