DCT - dopachrome tautomerase Gene

Also Known as OCA8; TRP-2; TYRP2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1638

About DCT

Cytogenetic location: 13q32.1 Genomic coordinates (GRCh38): 13:94,436,811-94,549,406 (from NCBI)

This gene has 5 transcripts (splice variants), 210 orthologues, 2 paralogues and is associated with 2 phenotypes. Restricted expression toward skin (RPKM 44.8).

Summary

Predicted to enable dopachrome isomerase activity. Involved in response to blue light. Located in intracellular membrane-bounded organelle and plasma membrane. Implicated in oculocutaneous albinism. [provided by Alliance of Genome Resources, Apr 2022]

DCT Products (7)

mRNA	Protein	Name
NM_001129889.3	NP_001123361.1	L-dopachrome tautomerase isoform 2 precursor
NM_001322182.2	NP_001309111.1	L-dopachrome tautomerase isoform 3
NM_001322183.2	NP_001309112.1	L-dopachrome tautomerase isoform 3
NM_001322184.2	NP_001309113.1	L-dopachrome tautomerase isoform 3
NM_001322185.2	NP_001309114.1	L-dopachrome tautomerase isoform 3
NM_001322186.2	NP_001309115.1	L-dopachrome tautomerase isoform 4
NM_001922.5	NP_001913.2	L-dopachrome tautomerase isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28842328	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in response to blue light	IDA IDA: Inferred from direct assay	28842328	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DCT Protein Structure

Tyrosinase

0
100
200
300
400
519 a.a.

Protein Preferred Names	Protein Names
L-dopachrome tautomerase	DT

DCT Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DCT	P40126	PLP1	Homo sapiens	P60201-2	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant DCT Proteins

Cat. No.	상품명	Accession	Purity
HY-P72168	DCT Protein, Human (His-SUMO)	P40126 (Q24-T472)	≥ 90%, as determined by reducing SDS-PAGE.

DCT Antibodies

Cat. No.	상품명	신청	Reactivity
HY-P81505	TRP2/DCT Antibody (YA1250)	IHC-P	Human
HY-P81505A	TRP2/DCT Antibody (YA1250)(PBS only)	IHC-P	Human
HY-P85700	TRP2/DCT Antibody (YA5392)	IHC-P, WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Oculocutaneous Albinism, Type Viii	OCA8 Oculocutaneous Albinism Type 8 Albinism, Oculocutaneous, 8
Albinism
Amelanotic Melanoma	Melanoma, Amelanotic Melanoma Amelanotic Amelanotic Skin Melanoma
Oculocutaneous Albinism	Albinism, Oculocutaneous Oca Albinism Oculocutaneous Oca - [Oculocutaneous Albinism]
Vitiligo-Associated Multiple Autoimmune Disease Susceptibility 1	Vitiligo VAMAS1 Slev1 Vtlg Systemic Lupus Erythematosus, Vitiligo-Related Vitiligo-Associated Multiple Autoimmune Disease 1 Systemic Lupus Erythematosus Vitiligo-Related
Chediak-Higashi Syndrome	CHS Chédiak-Higashi Syndrome Chediak - Steinbrinck Anomaly Chediak Higashi Syndrome Chediak-Steinbrinck-Higashi Syndrome Oculocutaneous Albinism With Leukocyte Defect Chediak-Higashi Disease Chediak-Higashi-Steinbrink Syndrome
Microphthalmia	Microphthalmos Isolated Anophthalmia-Microphthalmia Syndrome Isolated Microphthalmia-Anophthalmia-Coloboma Simple Microphthalmos Clinical Anophthalmia Isolated Anophthalmia - Microphthalmia Isolated Pure Microphthalmia Mac Spectrum Microphthalmia-Anophthalmia-Coloboma Spectrum Primitive Anophthalmia Globe Of Eye Small Small Eyeball Hypoplasia Of Eye Isolated Nanophthalmos Rudimentary Eye Dysplasia Of Eye
Albinism, Oculocutaneous, Type Iv	OCA4 Oculocutaneous Albinism Type 4 Oculocutaneous Albinism, Type Iv Oculocutaneous Albinism Type Iv Albinism, Oculocutaneous, 4
Hermansky-Pudlak Syndrome	Hps Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells Hermanski-Pudlak Syndrome Hermansky Pudlak Syndrome Platelet Storage Pool Deficiency
Albinism, Oculocutaneous, Type Iii	Rufous Oculocutaneous Albinism Oculocutaneous Albinism Type 3 OCA3 Roca Xanthism Oculocutaneous Albinism Type Iii Albinism Iii Oculocutaneous Albinism, Type Iii Albinism 3 Albinism, Oculocutaneous, Type 3 Rufous Oca Red Oculocutaneous Albinism Xanthous Oculocutaneous Albinism Albinism, Oculocutaneous, 3 Oca-Iii
Albinism, Oculocutaneous, Type Ib	OCA1B Oculocutaneous Albinism Type 1b Albinism, Yellow Mutant Type Yellow Albinism Oculocutaneous Albinism Type Ib Temperature-Sensitive Oculocutaneous Albinism Type 1 Oculocutaneous Albinism, Type Ib Yellow Mutant Albinism Oca1-Ts Ts Oca Type 1 Oculocutaneous Albinism, Amish Type Platinum Oculocutaneous Albinism Yellow Oculocutaneous Albinism Albinism, Oculocutaneous, 1b Albinism Yellow Mutant Type Oca-Ib Oca-Its Oculocutaneous Albinism Type I Temperature-Sensitive Albinism, Oculocutaneous, Type I, Temperature-Sensitive Minimal Pigment Oculocutaneous Albinism
Tietz Albinism-Deafness Syndrome	Tietz Syndrome Albinism-Deafness Of Tietz Hypopigmentation/Deafness Of Tietz Tietze'S Syndrome TADS Costochondral Junction Syndrome Costochondritis Tietze Syndrome Hypopigmentation-Deafness Syndrome Costalchondritis Slipping Rib Syndrome Tietze'S Disease Chondropathia Tuberosa Albinism And Complete Nerve Deafness Tietz'S Syndrome Hypopigmentation-Hearing Loss Syndrome Costal Chondritis Abnormality Of The Costochondral Junction
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Waardenburg'S Syndrome	Waardenburg Syndrome Van Der Hoeve Halbertsma Waardenburg Gualdi Syndrome Van Der Hoeve Halbertsona Waardenburg Syndrome Waardenburg Shah Syndrome Waardenburg, Types I And/Or Ii Mende Syndrome Waardenburgs Syndrome Waardenburg Syndrome, Type 4a
Waardenburg Syndrome, Type 2a	Waardenburg Syndrome Type 2a WS2A Waardenburg Syndrome, Type Iia Waardenburg Syndrome Without Dystopia Canthorum Ws2 Waardenburg Syndrome Type Iia Waardenburg Syndrome 2a
Piebald Trait	Piebaldism PBT Partial Albinism Albinoidism, Oculocutaneous, Autosomal Dominant
Acute Contagious Conjunctivitis	Pink Eye Contagious Opthalmia Pinkeye Conjunctivitis Keratoconjunctivitis Due To Mycoplasma Conjunctivae
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Melanoma, Cutaneous Malignant 1	Familial Melanoma Melanoma, Cutaneous Malignant, Susceptibility To, 1 Melanoma, Malignant CMM1 Melanoma, Cutaneous Malignant Cmm Familial Atypical Mole-Malignant Melanoma Syndrome Fammm Melanoma, Familial Mlm Dysplastic Nevus Syndrome, Hereditary Dns B-K Mole Syndrome Melanoma, Cutaneous Malignant, 1 Malignant Melanoma, Cutaneous Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1 Dysplastic Nevus Syndrome Cutaneous Melanoma Familial Atypical Mole Melanoma Syndrome Hereditary Melanoma
Melanoma, Uveal	Uveal Melanoma Choroidal Melanoma Melanoma Of Uvea Iris Melanoma Malignant Melanoma Of Choroid Malignant Melanoma Of Iris
Hirschsprung Disease 1	Hirschsprung Disease Aganglionic Megacolon Hscr Hirschsprung'S Disease Congenital Megacolon Congenital Intestinal Aganglionosis Colonic Aganglionosis Hirschsprung Disease, Susceptibility To, 1 Hirschsprung Disease, Protection Against HSCR1 Mgc Pelvirectal Achalasia Total Intestinal Aganglionosis Megacolon, Aganglionic Macrocolon Hscr 1 Hirschsprung Disease Type 1 Hirschsprung Disease, Type 1 Congenital Dilatation Of Colon Aganglionosis Congenital Aganglionic Megacolon Aganglionosis Of Colon Bowel Aganglionosis Colon Aganglionosis Hirschsprung Megacolon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-113042	Prostaglandin B2		≥99.0%	Unkown

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-D0168	Orcinol		99.97%	Unkown
HY-138561C	EFdA-TP tetralithium	Inhibitor	96.91%	Unkown
HY-N2983	Cajanin	Inhibitor	99.96%	Unkown
HY-138561A	EFdA-TP tetraammonium	Inhibitor	98.03%	Unkown
HY-138561B	EFdA-TP tetrasodium	Inhibitor	95.18%	Unkown
HY-138561	EFdA-TP	Inhibitor	/	Unkown
HY-148412	Monarsen	Inhibitor	/	Unkown
HY-RS03591	DCT Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174722	Human DCT mRNA		/	Unkown
HY-RS17790	Dct Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24258	Dct Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	DCT	VGNC	VGNC:39814
Macaca mulatta	DCT	VGNC	VGNC:71749
Bos taurus	DCT	VGNC	VGNC:27926
Rattus norvegicus	DCT	RGD	RGD:1564975
Mus musculus	DCT	MGD	MGI:102563
Felis catus	DCT	VGNC	VGNC:61377
Others	DCT	NCBI