Sirpa - signal-regulatory protein alpha Gene

Also Known as Bit; P84; SIRP; SHP-1; CD172a; Ptpns1; SHPS-1; Idd13.2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19261

Summary

Enables protein Phosphatase binding activity and protein phosphorylated amino acid binding activity. Involved in several processes, including negative regulation of MAPK cascade; negative regulation of cytokine production; and negative regulation of nitrogen compound metabolic process. Acts upstream of or within several processes, including hematopoietic progenitor cell differentiation; phagocytosis; and positive regulation of phagocytosis. Is integral component of plasma membrane. Is expressed in several structures, including adrenal gland; cartilage; central nervous system; genitourinary system; and retina. Orthologous to several human genes including SIRPA (signal regulatory protein alpha). [provided by Alliance of Genome Resources, Apr 2022]

Sirpa Products (8)

mRNA Protein Name
NM_001177647.2 NP_001171118.1 tyrosine-protein phosphatase non-receptor type substrate 1 isoform 2 precursor
NM_001291019.1 NP_001277948.1 tyrosine-protein phosphatase non-receptor type substrate 1 isoform 3 precursor
NM_001291020.1 NP_001277949.1 tyrosine-protein phosphatase non-receptor type substrate 1 isoform 3 precursor
NM_001291021.1 NP_001277950.1 tyrosine-protein phosphatase non-receptor type substrate 1 isoform 4 precursor
NM_001291022.1 NP_001277951.1 tyrosine-protein phosphatase non-receptor type substrate 1 isoform 5 precursor
NM_001355158.1 NP_001342087.1 tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1 precursor
NM_001355160.1 NP_001342089.1 tyrosine-protein phosphatase non-receptor type substrate 1 isoform 6
NM_007547.4 NP_031573.2 tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11895767 MGI
enables protein phosphatase binding IPI
IPI: Inferred from physical interaction
17954568 MGI
enables protein phosphorylated amino acid binding IPI
IPI: Inferred from physical interaction
12393607 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within actin filament organization IMP
IMP: Inferred from mutant phenotype
11118207 MGI
acts upstream of or within cell motility IMP
IMP: Inferred from mutant phenotype
11118207 MGI
acts upstream of or within cell-matrix adhesion IMP
IMP: Inferred from mutant phenotype
11118207 MGI
involved in cellular response to lipopolysaccharide IDA
IDA: Inferred from direct assay
17954568 MGI
acts upstream of or within cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
11118207 MGI
involved in granulocyte migration IGI
IGI: Inferred from genetic interaction
24026300 MGI
acts upstream of or within hematopoietic progenitor cell differentiation IMP
IMP: Inferred from mutant phenotype
24029230 MGI
involved in negative regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
17954568 MGI
involved in negative regulation of I-kappaB phosphorylation IMP
IMP: Inferred from mutant phenotype
17954568 MGI
involved in negative regulation of JNK cascade IMP
IMP: Inferred from mutant phenotype
17954568 MGI
involved in negative regulation of chemokine (C-C motif) ligand 5 production IMP
IMP: Inferred from mutant phenotype
17954568 MGI
involved in negative regulation of cytokine production involved in inflammatory response IGI
IGI: Inferred from genetic interaction
23562609 MGI
involved in negative regulation of cytokine production involved in inflammatory response IMP
IMP: Inferred from mutant phenotype
17954568 MGI
involved in negative regulation of interferon-beta production IMP
IMP: Inferred from mutant phenotype
17954568 MGI
involved in negative regulation of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
17954568 MGI
involved in negative regulation of macrophage inflammatory protein 1 alpha production IMP
IMP: Inferred from mutant phenotype
17954568 MGI
involved in negative regulation of nitric oxide biosynthetic process IMP
IMP: Inferred from mutant phenotype
17954568 MGI
involved in negative regulation of phagocytosis IMP
IMP: Inferred from mutant phenotype
21401967 MGI
involved in negative regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
17954568 MGI
involved in negative regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
17954568 MGI
acts upstream of or within phagocytosis, engulfment IDA
IDA: Inferred from direct assay
14634079 MGI
acts upstream of or within phagocytosis, recognition IDA
IDA: Inferred from direct assay
14634079 MGI
acts upstream of or within positive regulation of phagocytosis IDA
IDA: Inferred from direct assay
14634079 MGI
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
14634079 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tyrosine-protein phosphatase non-receptor type substrate 1

  • CD172 antigen-like family member A

  • SHP substrate 1

  • brain Ig-like molecule with tyrosine-based activation motifs

  • brain immunological-like with tyrosine-based motifs

  • inhibitory receptor SHPS-1

  • mSIRP-alpha1

  • myD-1 antigen

  • protein tyrosine phosphatase,

Recombinant Sirpa Proteins

Cat. No. 상품명 Accession Purity
HY-P72468 SIRP alpha/CD172a Protein, Mouse (HEK293, His) P97797-1/Q6P6I8/BAA13520.1 (K32-N373) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P76071 SIRP alpha/CD172a Protein, Mouse (BAA20376, HEK293, Fc) BAA20376.1 (T32-N373) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P78661 SIRP alpha/CD172a Protein, Mouse (G365D, HEK293, mFc) P97797-1 (K32-N373, G365D) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (2)
Cat. No. 상품명 효과
Purity Phase
HY-P991693 Ipsoprubart Inhibitor 97% Phase 3
HY-P991016 Peluntamig 99.9% Phase 2

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS12932 SIRPA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17207 Sirpa Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23659 Sirpa Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (3)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-P990555 BI-765063 Inhibitor 97.89% Unkown
HY-P990723 Timdarpacept Inhibitor 99.95% Unkown
HY-P992346 DS-1103a Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sirpa NCBI NCBI:140885