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EIF5A - eukaryotic translation initiation factor 5A Gene

Also Known as FABAS; EIF-5A; EIF5A1; eIF-4D; eIF5AI

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1984

About EIF5A

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,306,999-7,312,463 (from NCBI)

This gene has 11 transcripts (splice variants), 1 gene allele, 207 orthologues, 2 paralogues and is associated with 2 phenotypes. Ubiquitous expression in esophagus (RPKM 53.8), appendix (RPKM 49.4) and 25 other tissues.

Summary

Enables U6 snRNA binding activity and protein N-terminus binding activity. Involved in several processes, including cellular response to virus; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator; and tumor necrosis factor-mediated signaling pathway. Located in annulate lamellae; cytoplasm; and nucleus. Part of nuclear pore. [provided by Alliance of Genome Resources, Apr 2022]

EIF5A Products (6)

mRNA	Protein	Name
NM_001143760.1	NP_001137232.1	eukaryotic translation initiation factor 5A-1 isoform A
NM_001143761.1	NP_001137233.1	eukaryotic translation initiation factor 5A-1 isoform B
NM_001143762.2	NP_001137234.1	eukaryotic translation initiation factor 5A-1 isoform B
NM_001370420.1	NP_001357349.1	eukaryotic translation initiation factor 5A-1 isoform B
NM_001370421.1	NP_001357350.1	eukaryotic translation initiation factor 5A-1 isoform B
NM_001970.5	NP_001961.1	eukaryotic translation initiation factor 5A-1 isoform B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA binding	IDA IDA: Inferred from direct assay	15303967	GOA
enables U6 snRNA binding	IDA IDA: Inferred from direct assay	9285100	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9442029	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to virus	IMP IMP: Inferred from mutant phenotype	8596953	GOA
involved in positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator	IDA IDA: Inferred from direct assay	15371445	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	15371445	GOA
involved in translational elongation	IMP IMP: Inferred from mutant phenotype	29712776	GOA
involved in tumor necrosis factor-mediated signaling pathway	IDA IDA: Inferred from direct assay	17187778	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in annulate lamellae	IDA IDA: Inferred from direct assay	12210765	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	12210765	GOA
part of nuclear pore	IDA IDA: Inferred from direct assay	10381392	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12210765	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF5A Protein Structure

eIF-5a

0
100
154 a.a.

Protein Preferred Names	Protein Names
eukaryotic translation initiation factor 5A-1	eukaryotic initiation factor 5A

EIF5A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	EIF5A	P63241	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	EIF5A	P63241	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	EIF5A	P63241	REL	Homo sapiens	Q04864-2	Validated Y2H	32296183
Intra	EIF5A	P63241	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	EIF5A	P63241	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	EIF5A	P63241	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	EIF5A	P63241	MEI4	Homo sapiens	A8MW99	Y2H Array	32296183
Intra	EIF5A	P63241	MEI4	Homo sapiens	A8MW99	Y2H Prey Pooling	32296183
Intra	EIF5A	P63241	GSC2	Homo sapiens	O15499	Y2H Array	32296183
Intra	EIF5A	P63241	GSC2	Homo sapiens	O15499	Y2H Prey Pooling	32296183
Intra	EIF5A	P63241	LBX1	Homo sapiens	P52954	Y2H Array	32296183
Intra	EIF5A	P63241	LBX1	Homo sapiens	P52954	Y2H Prey Pooling	32296183
Intra	EIF5A	P63241	REL	Homo sapiens	Q04864	Y2H Prey Pooling	25416956
Intra	EIF5A	P63241	REL	Homo sapiens	Q04864	Validated Y2H	25416956
Intra	EIF5A	P63241	SDCBP	Homo sapiens	O00560	Y2H Array	32296183
Intra	EIF5A	P63241	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	32296183
Intra	EIF5A	P63241	DHPS	Homo sapiens	P49366	Validated Y2H	25416956
Intra	EIF5A	P63241	CRX	Homo sapiens	O43186	Validated Y2H	25416956
Intra	EIF5A	P63241	CRX	Homo sapiens	O43186	Y2H Prey Pooling	25416956
Intra	EIF5A	P63241	MEOX2	Homo sapiens	P50222	Y2H Prey Pooling	25416956
Intra	EIF5A	P63241	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	EIF5A	P63241	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
Intra	EIF5A	P63241	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EIF5A Proteins

Cat. No.	상품명	Accession	Purity
HY-P78232	EIF5A Protein, Human (His)	NP_001961 (M1-K154)	≥ 95%, as determined by reducing SDS-PAGE.

EIF5A Antibodies

Cat. No.	상품명	신청	Reactivity
HY-P80653	eIF5A Antibody (YA461)	WB, IHC-P, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Faundes-Banka Syndrome	FABAS
Human Immunodeficiency Virus Type 1	Aids Hiv/Aids Aids, Delayed/Rapid Progression To Hiv-1, Susceptibility To Hiv-1 Viremia, Susceptibility To Human Immunodeficiency Virus Type 1, Susceptibility To Hiv-1 Aids, Slow Progression To Rapid Progression To Aids From Hiv1 Infection Hiv1 Infection, Resistance To Hiv1 Infection Hiv-1 Viremia Aids, Resistance To Aids, Rapid Progression To Hiv/Aids, Susceptibility To Hiv-1, Resistance To Hiv1, Resistance To Hiv1 Hiv-1 Disease, Delayed Progression Of Hiv-1 Disease, Rapid Progression Of Hiv Infection, Resistance To Hiv Type 1, Susceptibility To Hiv Type 1 Hiv-1 Infection Human Immunodeficiency Virus I Infection Acquired Immunodeficiency Syndrome Hiv-Infection/Aids
Syndromic X-Linked Intellectual Disability Snyder Type	Snyder-Robinson Syndrome Mental Retardation, X-Linked, Snyder-Robinson Type Spermine Synthase Deficiency Srs Snyder-Robinson Mental Retardation Syndrome X-Linked Intellectual Disability Snyder-Robinson Type Mental Retardation, X-Linked, Syndromic, Snyder-Robinson Type Snyder-Robinson X-Linked Mental Retardation Syndrome
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-N2397	9''-Methyl salvianolate B		99.54%	Unkown
HY-111522	RK-9123016	Inhibitor	99.65%	Unkown
HY-106801	Girolline		/	Unkown
HY-RS04286	EIF5A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W141446	VT00065	Inhibitor	≥98.0%	Unkown
HY-121722	Deoxyhypusine		/	Unkown
HY-122039	Hypusine dihydrochloride		/	Unkown
HY-RS04285	EIF5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04287	EIF5A2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-126171	Hypusine		/	Unkown
HY-RS19060	Eif5a2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19678	Eif5a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25550	Eif5a2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26171	Eif5a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	EIF5A	MGD	MGI:106248
Rattus norvegicus	EIF5A	RGD	RGD:1308029
Others	EIF5A	NCBI