Ern1 - endoplasmic reticulum (ER) to nucleus signalling 1 Gene

Also Known as Ire1a; Ire1p; Ire1alpha; 9030414B18Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 78943

About Ern1

Chromosome 11: 106,285,476-106,378,678 reverse strand.GRCm39:CM001004.3

This gene has 5 transcripts (splice variants), 133 orthologues, 1 paralogue and is associated with 17 phenotypes. Broad expression in adrenal adult (RPKM 76.6), ovary adult (RPKM 25.1) and 15 other tissues.

Summary

Enables endoribonuclease activity; protein homodimerization activity; and protein serine/threonine kinase activity. Involved in several processes, including IRE1-mediated unfolded protein response; mRNA cleavage; and positive regulation of nitrogen compound metabolic process. Acts upstream of or within endoplasmic reticulum unfolded protein response; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and protein autophosphorylation. Located in endoplasmic reticulum membrane; mitochondrion; and nuclear inner membrane. Part of AIP1-IRE1 complex. Is expressed in several structures, including brain; connective tissue; gut; hemolymphoid system gland; and tooth. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human ERN1 (endoplasmic reticulum to nucleus signaling 1). [provided by Alliance of Genome Resources, Apr 2022]

Ern1 Products (1)

mRNA	Protein	Name
NM_023913.2	NP_076402.1	serine/threonine-protein kinase/endoribonuclease IRE1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA endonuclease activity	IDA IDA: Inferred from direct assay	15601821	MGI
enables endonuclease activity	IDA IDA: Inferred from direct assay	11850408	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16680093	MGI
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	25164867	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	25164867	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in IRE1-mediated unfolded protein response	IDA IDA: Inferred from direct assay	24508390	MGI
acts upstream of or within endoplasmic reticulum unfolded protein response	IDA IDA: Inferred from direct assay	10882126	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	11146108	MGI
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	11146108	MGI
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	19328063	MGI
involved in positive regulation of JUN kinase activity	IMP IMP: Inferred from mutant phenotype	10650002	MGI
involved in positive regulation of RNA splicing	IDA IDA: Inferred from direct assay	25164867	MGI
acts upstream of or within protein autophosphorylation	IDA IDA: Inferred from direct assay	11430819	MGI
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	25164867	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of AIP1-IRE1 complex	IPI IPI: Inferred from physical interaction	18281285	MGI
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	9755171	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	23028046	MGI
located in nuclear inner membrane	IDA IDA: Inferred from direct assay	11850408	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ern1 Protein Structure

Luminal_IRE1

STKc_IRE1

RNase_Ire1

0
200
400
600
800
977 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein kinase/endoribonuclease IRE1	endoplasmic reticulum-to-nucleus signaling 1 inositol-requiring 1 alpha inositol-requiring protein 1 ire1-alpha

Ern1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Ern1	Q9EQY0	Traf6	Mus musculus	P70196	Anti Tag CoIP	23942232
Intra	Ern1	Q9EQY0	Tnfrsf1a	Mus musculus	P25118	Anti Bait CoIP	16680093

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-174497	eGFP mRNA		90%	Unkown
HY-136735	IRE1α kinase-IN-1	Inhibitor	98.94%	Unkown
HY-RS04509	Ern1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04507	ERN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04508	Ern1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ern1	NCBI	NCBI:2081