TNFRSF14 - TNF receptor superfamily member 14 Gene

Also Known as TR2; ATAR; HVEA; HVEM; CD270; LIGHTR

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8764

About TNFRSF14

Cytogenetic location: 1p36.32 Genomic coordinates (GRCh38): 1:2,554,234-2,563,829 (from NCBI)

This gene has 16 transcripts (splice variants), 1 gene allele, 538 orthologues, 21 paralogues and is associated with 66 phenotypes. Ubiquitous expression in spleen (RPKM 22.9), duodenum (RPKM 21.7) and 23 other tissues.

Summary

This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

TNFRSF14 Products (2)

mRNA	Protein	Name
NM_001297605.2	NP_001284534.1	tumor necrosis factor receptor superfamily member 14 isoform 2 precursor
NM_003820.4	NP_003811.2	tumor necrosis factor receptor superfamily member 14 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cytokine binding	IPI IPI: Inferred from physical interaction	27152329	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9153189	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	11279055	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in T cell costimulation	IDA IDA: Inferred from direct assay	10754304	GOA
involved in negative regulation of adaptive immune memory response	IDA IDA: Inferred from direct assay	18193050	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	18193050	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNFRSF14 Protein Structure

TNFR_c6

0
100
200
283 a.a.

Protein Preferred Names	Protein Names
tumor necrosis factor receptor superfamily member 14	CD40-like protein

TNFRSF14 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TNFRSF14	Q92956	TRAF2	Homo sapiens	Q12933	Anti Bait CoIP	17353931
Intra	TNFRSF14	Q92956	TRAF2	Homo sapiens	Q12933	Anti Bait CoIP	19332782
Intra	TNFRSF14	Q92956	TRAF2	Homo sapiens	Q12933-2	Pull Down	9162022
Intra	TNFRSF14	Q92956	TRAF5	Homo sapiens	O00463	Pull Down	9162022
Intra	TNFRSF14	Q92956	TNFSF14	Homo sapiens	O43557	Yeast Display	26977880
Intra	TNFRSF14	Q92956	TNFSF14	Homo sapiens	O43557	FACS	9462508
Intra	TNFRSF14	Q92956	FOXD4L6	Homo sapiens	Q3SYB3	Y2H Pooling	32814053
Intra	TNFRSF14	Q92956	FOXD4L6	Homo sapiens	Q3SYB3	Validated Y2H	32814053
Intra	TNFRSF14	Q92956	FOXD4L6	Homo sapiens	Q3SYB3	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TNFRSF14 Proteins

Cat. No.	상품명	Accession	Purity
HY-P7366	HVEM/TNFRSF14 Protein, Human (sf9, Fc)	Q92956 (L39-K184)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70489	HVEM/TNFRSF14 Protein, Human (HEK293, His)	Q92956 (L39-V202)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78798	HVEM/TNFRSF14 Protein, Human (Biotinylated, HEK293, Fc-Avi)	Q92956-1 (L39-V202)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700452	HVEM/TNFRSF14 Protein, Human (HEK293, hFc)	Q92956 (L39-V202)	≥ 90%, as determined by reducing SDS-PAGE.

TNFRSF14 Antibodies

Cat. No.	상품명	신청	Reactivity
HY-P81597	HVEM Antibody (YA1342)	FC, ELISA	Human

Related Diseases

Diseases	Alias
Herpes Simplex	Herpes Simplex Infections Herpesvirus Hominis Disease Herpes Simplex Disease Herpesviral Infection Due To Herpes Simplex Infections Due To Simplex Virus Herpes Nos
Ezb Diffuse Large B-Cell Lymphoma	Ezb Dlbcl Doid:0081065
Herpetic Whitlow	Herpetic Felon
Genital Herpes	Herpes Genitalis Genital Herpes Simplex Venereal Herpes Virus-Genital Herpes
Acute Retinal Necrosis Syndrome	Acute Retinal Necrosis Retinal Necrosis Syndrome, Acute
Nodal Marginal Zone Lymphoma	Mucosa-Associated Lymphoid Tissue Lymphoma Monocytoid B-Cell Lymphoma
Type 1 Diabetes Mellitus 21	Diabetes Mellitus, Insulin-Dependent, 21 Iddm21 T1D21 Insulin-Dependent Diabetes Mellitus 21
Cone-Rod Dystrophy 2	Cone-Rod Dystrophy CORD2 Cone-Rod Retinal Dystrophy Rcrd2 Cone-Rod Retinal Dystrophy 2 Crd2 Cord Crd Retinal Cone-Rod Dystrophy Cone-Rod Retinal Dystrophy-2 Retinal Cone-Rod Dystrophy 2 Tapetoretinal Degeneration Cone-Rod Degeneration Cone Rod Dystrophy Dystrophy, Cone-Rod Dystrophy, Cone-Rod, Type 2 Retinitis Pigmentosa Retinitis Pigmentosa 2 Progressive Cone-Rod Dystrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS14806	TNFRSF14 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174517	Human TNFRSF14 mRNA		/	Unkown
HY-RS17316	Tnfrsf14 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23771	Tnfrsf14 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TNFRSF14	VGNC	VGNC:80387
Macaca mulatta	TNFRSF14	VGNC	VGNC:78585
Canis familiaris	TNFRSF14	VGNC	VGNC:47658
Rattus norvegicus	TNFRSF14	RGD	RGD:1310115
Mus musculus	TNFRSF14	MGD	MGI:2675303
Others	TNFRSF14	NCBI