GR 94800 TFA
GR 94800 TFA is a potent and selective NK2 receptor peptide antagonist, with pKB values of 9.6, 6.4 and 6.0 for NK2, NK1 and NK3 receptors, respectively.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- 화학식: C49H61N9O8·xC2HF3O2
- 분자량:904.06 (free base)
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- 순도&문서
- References
-
Help & FAQs
Biological Activity
|
NK2R |
Responses to EFS (15 Hz) were significantly reduced by the NK2 receptor antagonist GR 94800 (1 μM) either alone or in combination with the NK1 antagonist (1 μM)[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
분자량 904.06 (free base)
-
화학식 C49H61N9O8·xC2HF3O2
-
Sequence
Bz-Ala-Ala-{D-Trp}-Phe-{D-Pro}-Pro-{Nle}-NH2
-
Sequence Shortening
Bz-AA-{D-Trp}-F-{D-Pro}-P-{Nle}-NH2
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. A B McElroy, et al. Highly potent and selective heptapeptide antagonists of the neurokinin NK-2 receptor. J Med Chem. 1992 Jul 10;35(14):2582-91. [Content Brief]
[2]. M A Matuszek, et al. An investigation of tachykinin NK2 receptor subtypes in the rat. Eur J Pharmacol. 1998 Jul 3;352(1):103-9. [Content Brief]
[3]. Stephen D Tichenor, et al. Excitatory motor innervation in the canine rectoanal region: role of changing receptor populations. Br J Pharmacol. 2002 Dec;137(8):1321-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GR 94800 TFA Related Classifications
HY-P1277A Related Classifications
Powered by Bioz