Illudalic acid
Illudalic acid is a sesquiterpenoid natural product discovered in Omphalotus illudens. Illudalic acid inhibits LAR with an IC50 of 2.1 µM, and also inhibits CD45, PTPμ, and SHP2. Illudalic acid derivatives inhibit PTPRD and reduce drug-induced reward behavior in animal models. Illudalic acid can be used in research on LAR-related diseases.
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- CAS No.: 18508-77-5
- 화학식: C15H16O5
- 분자량:276.28
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
IC50 & Target
IC50: 1.30 µM (LAR phosphatase)[1]
In Vitro
Illudalic acid (IA-30) inhibits LAR with an IC50 of 2.1 µM, and also inhibits CD45 (10 µM), PTPμ (16 µM), and SHP2 (29 µM), whereas its IC50 values against TCPTP, HePTP, PTPε, VHR, and LMWPTP are all >100 µM[3].
Illudalic acid is a pseudo-irreversible LAR inhibitor, KI = 130 µM, kinact = 1.3 min-1[3].
Illudalic acid (20 μM; 10 min) irreversibly inhibits recombinant LAR[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 18508-77-5
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분자량 276.28
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화학식 C15H16O5
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SMILES
CC1(CC2=C(C(C=O)=C3CC(OC(C3=C2C1)=O)O)O)C
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Structure Classification
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Initial Source
Clitocybe illudens
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocol
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Protocol for Sucrose Preference Test (SPT)
The Sucrose Preference Test is a rodent two-bottle choice assay used to estimate reward-related behavior by measuring preference for a sweet sucrose solution over water. Reduced sucrose preference is commonly interpreted as an anhedonia-like phenotype in stress-based depression models, but it can also be affected by thirst, hunger, body weight, learning, motivation, and general fluid intake.
순도&문서
References
[2]. Uhl GR, et al. Cocaine reward is reduced by decreased expression of receptor-type protein tyrosine phosphatase D (PTPRD) and by a novel PTPRD antagonist. Proceedings of the National Academy of Sciences of the United States of America. 2018 Nov 06;115(45):11597-11602. [Content Brief]
[4]. Ling Q, et al. Illudalic acid as a potential LAR inhibitor: synthesis, SAR, and preliminary studies on the mechanism of action. Bioorganic & medicinal chemistry. 2008 Aug 01;16(15):7399-409. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Illudalic acid Related Classifications
HY-N12776 Related Classifications
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