K1586
Based on 1 Customer Validation
K1586 is an amidine derivative that efficiently targets Chk1. K1586 enhances the degradation of Chk1 that sensitizes colorectal cancer cells to ionizing radiation. K1586 shows anticancer effects.
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- Purity: 99.63%
- 화학식: C18H18ClN3OS
- 분자량:359.87
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보관:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
K1586 (0.001-100 μM; 72 h) decreases cell proliferation in a dose-dependent manner[1].
K1586 (10-20 μM; 24 h) increases the relative length of the S phase and significant increases the length of the G2/M phase[1].
K1586 (10 μM; 12 h) decreases Chk1 protein levels in a time-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HT29 human colorectal cancer cells
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Concentration:0.001 μM, 0.01 μM, 0.1 μM, 1 μM, 5 μM, 10 μM, 50 μM, and 100 μM
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Incubation Time:72 h
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Result:Proliferation decreased in a dose-dependent manner.
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Cell Line:HT29 cells
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Concentration:10 or 20 μM
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Incubation Time:24 h
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Result:Increased the length of the G2/M phase in cells.
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Cell Line:HT29 cells
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Concentration:10 μM
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Incubation Time:12 h
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Result:Induced Chk1 destabilization and degradation.
Chemical Information
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Appearance Solid
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분자량 359.87
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화학식 C18H18ClN3OS
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Color White to off-white
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SMILES
CCN(CC)/C=N/C(C=C1)=CC2=C1N=C(S2)OC3=CC=C(Cl)C=C3
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 50 mg/mL (138.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7788 mL | 13.8939 mL | 27.7878 mL | 69.4695 mL |
| 5 mM | 0.5558 mL | 2.7788 mL | 5.5576 mL | 13.8939 mL | |
| 10 mM | 0.2779 mL | 1.3894 mL | 2.7788 mL | 6.9470 mL | |
| 15 mM | 0.1853 mL | 0.9263 mL | 1.8525 mL | 4.6313 mL | |
| 20 mM | 0.1389 mL | 0.6947 mL | 1.3894 mL | 3.4735 mL | |
| 25 mM | 0.1112 mL | 0.5558 mL | 1.1115 mL | 2.7788 mL | |
| 30 mM | 0.0926 mL | 0.4631 mL | 0.9263 mL | 2.3157 mL | |
| 40 mM | 0.0695 mL | 0.3473 mL | 0.6947 mL | 1.7367 mL | |
| 50 mM | 0.0556 mL | 0.2779 mL | 0.5558 mL | 1.3894 mL | |
| 60 mM | 0.0463 mL | 0.2316 mL | 0.4631 mL | 1.1578 mL | |
| 80 mM | 0.0347 mL | 0.1737 mL | 0.3473 mL | 0.8684 mL | |
| 100 mM | 0.0278 mL | 0.1389 mL | 0.2779 mL | 0.6947 mL |
K1586 Related Classifications
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