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Cat. No.: HY-159111

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KS124

KS124 (compound 3) is a potent ALDH inhibitor. KS124 shows inhibition for ALDH1A1, ALDH1A3, ALDH3A1. KS124 shows antiproliferative activity. KS124 induces apoptosis and ROS production.

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화학식: C₂₁H₁₂Br₂N₂O₇
분자량:564.14

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

KS124 Chemical Structure

사이즈

가격

재고

수량

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Aldehyde Dehydrogenase (ALDH) Isoforms :

In Vitro

KS124 (compound 3) (3 µM; 24, 48 h) induces apoptosis in a time-dependent manner in HCT-116 cells^[1].
KS124 (3 µM; 48 h) increases ROS production in HCT-116 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

HCT-116, SKOV-3, MIA PaCa-2, HEK-293, FHC cells
Concentration:

0-50 µM
Incubation Time:

48 h
Result:

Inhibited cell viability with IC₅₀s of 2.2, 3.8, 2.1, 8.7, 7.1 µM for HCT-116, SKOV-3, MIA PaCa-2, HEK-293, FHC cells, respectively.

Apoptosis Analysis^[1]

Cell Line:

HCT-116 cells
Concentration:

3 µM
Incubation Time:

24 h, 48 h
Result:

Induced apoptosis with the late apoptotic cell populations of 12.30%, 15.45% at 24, 48 h, respectively.

Chemical Information

분자량 564.14
화학식 C₂₁H₁₂Br₂N₂O₇
SMILES

O=C(C1=CC=C([N+]([O-])=O)O1)OCC2=CC=C(CN3C(C(C4=C3C(Br)=CC(Br)=C4)=O)=O)C=C2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Gowda K, et al. Identification of Novel Isatin Derivative Bearing a Nitrofuran Moiety as Potent Multi-Isoform Aldehyde Dehydrogenase Inhibitor. Molecules. 2024 Jun 29;29(13):3114. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
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Purity:
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KS124

All Aldehyde Dehydrogenase (ALDH) Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

KS124 Related Classifications

HY-159111 Related Classifications