MI 63
MI 63 is an activator for p53, by targeting the MDM2 (Ki is 3 nM). MI 63 inhibits the proliferation of embryonic and alveolar rhabdomyosarcoma (ERMS and ARMS) cells (IC50 is 0.58 μM in RH36 cells), and induces apoptosis in ERMS and ARMS.
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- CAS No.: 908027-21-4
- 화학식: C29H35Cl2FN4O3
- 분자량:577.52
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A2780 | GI50 |
1.19 μM
Compound: 2a, MI-63
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Growth inhibition of human A2780 cells expressing MDM2 by SRB assay
Growth inhibition of human A2780 cells expressing MDM2 by SRB assay
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[PMID: 21875801] |
| HCT-116 | GI50 |
1.3 μM
Compound: 2a, MI-63
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Growth inhibition of human HCT116 cells expressing MDM2 by SRB assay
Growth inhibition of human HCT116 cells expressing MDM2 by SRB assay
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[PMID: 21875801] |
| HCT-116 | GI50 |
11.8 μM
Compound: 2a, MI-63
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Growth inhibition of p53 deficient human HCT116 cells expressing MDM2 by SRB assay
Growth inhibition of p53 deficient human HCT116 cells expressing MDM2 by SRB assay
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[PMID: 21875801] |
| HCT-116 | IC50 |
0.7 μM
Compound: 1, MI-63
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Growth inhibition of human HCT116 cells expressing wild type p53 gene after 4 days by WST8 dye reduction assay
Growth inhibition of human HCT116 cells expressing wild type p53 gene after 4 days by WST8 dye reduction assay
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[PMID: 19928922] |
| HCT-116 | IC50 |
14.4 μM
Compound: 1, MI-63
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Growth inhibition of human HCT116 cells deficient in p53 gene expression after 4 days by WST8 dye reduction assay
Growth inhibition of human HCT116 cells deficient in p53 gene expression after 4 days by WST8 dye reduction assay
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[PMID: 19928922] |
| LNCaP | IC50 |
280 nM
Compound: 8, MI-63
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Antiproliferative activity against human LnCAP cell line with wild type p53
Antiproliferative activity against human LnCAP cell line with wild type p53
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[PMID: 16759082] |
| PC-3 | IC50 |
18 μM
Compound: 8, MI-63
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Antiproliferative activity against human PC3 cell line with deleted p53
Antiproliferative activity against human PC3 cell line with deleted p53
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[PMID: 16759082] |
| SAOS-2 | IC50 |
14.1 μM
Compound: 1, MI-63
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Growth inhibition of human Saos2 cells deficient in p53 gene expression after 4 days by WST8 dye reduction assay
Growth inhibition of human Saos2 cells deficient in p53 gene expression after 4 days by WST8 dye reduction assay
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[PMID: 19928922] |
| SJSA-1 | GI50 |
0.55 μM
Compound: 2a, MI-63
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Growth inhibition of human SJSA1 cells expressing MDM2 by SRB assay
Growth inhibition of human SJSA1 cells expressing MDM2 by SRB assay
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[PMID: 21875801] |
| SJSA-1 | IC50 |
0.5 μM
Compound: 1, MI-63
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Growth inhibition of human SJSA1 cells expressing wild type p53 gene after 4 days by WST8 dye reduction assay
Growth inhibition of human SJSA1 cells expressing wild type p53 gene after 4 days by WST8 dye reduction assay
|
[PMID: 19928922] |
Chemical Information
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CAS No. 908027-21-4
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분자량 577.52
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화학식 C29H35Cl2FN4O3
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SMILES
O=C([C@H](N[C@@H]1CC(C)(C)C)[C@H](C2=CC=CC(Cl)=C2F)[C@]31C(NC4=C3C=CC(Cl)=C4)=O)NCCN5CCOCC5
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MI 63 Related Classifications
HY-18330 Related Classifications
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