MMG-0358
MMG-0358 is a potent IDO1 inhibitor. MMG-0358 shows IC50 values of 2 nM in a cellular assay on mIDO1, 80 nM in a cellular assay on hIDO1, 330 nM in an enzymatic assay on hIDO1 at pH 6.5, and 71 nM in an enzymatic assay on hIDO1 at pH 7.4.
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- CAS No.: 1378976-02-3
- 화학식: C8H6ClN3O
- 분자량:195.61
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
IC50 & Target
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IDO1 330 nM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
0.082 μM
Compound: MMG-0358
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Inhibition of IDO1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine levels after 48 hrs
Inhibition of IDO1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine levels after 48 hrs
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[PMID: 31525930] |
| P815 | IC50 |
>100 μM
Compound: 35, MMG-0358
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Inhibition of mouse TDO in P815 clone 12 cells by HPLC analysis
Inhibition of mouse TDO in P815 clone 12 cells by HPLC analysis
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[PMID: 22616902] |
| P815 | IC50 |
0.002 μM
Compound: 35, MMG-0358
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Inhibition of mouse IDO1 in P815 clone 6 cells by HPLC analysis
Inhibition of mouse IDO1 in P815 clone 6 cells by HPLC analysis
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[PMID: 22616902] |
Chemical Information
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CAS No. 1378976-02-3
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분자량 195.61
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화학식 C8H6ClN3O
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SMILES
ClC1=CC(C2=CN=NN2)=C(O)C=C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MMG-0358 Related Classifications
HY-120742 Related Classifications
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