NMDA receptor antagonist 9
NMDA receptor antagonist 9 is a selective GluN2B subunit-containing NMDA receptor antagonist with a Ki of 5.2 nM. NMDA receptor antagonist 9 exhibits 9-fold selectivity over σ1 receptors, shows poor selectivity towards σ2 receptors. NMDA receptor antagonist 9 inhibits ion flux through GluN2B subunit-containing NMDA receptors. NMDA receptor antagonist 9 can be used for the research of neurological disease, such as alzheimer’s disease and parkinson’s disease.
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- 화학식: C21H25NO2
- 분자량:323.43
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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GluN2B 5.2 nM (Ki) |
σ2 4.2 nM (Ki) |
σ1 49 nM (Ki) |
NMDA receptor antagonist 9 (Compound cis-15a) binds to GluN2B subunit-containing NMDA receptors in recombinant L(tk-) cells with a Ki of 5.2 ± 1.9 nM[1].
NMDA receptor antagonist 9 (1 μM) inhibits ion flux at GluN2B subunit-containing NMDA receptors expressed in Xenopus laevis oocytes by 76 ± 2%[1].
NMDA receptor antagonist 9 binds to σ1 and σ2 receptors in guinea pig brain membranes with a Ki of 49 ± 7 and 4.2 ± 0.6 nM[1].
NMDA receptor antagonist 9 (90 min at 37 °C) exhibits high phase I metabolic stability in mouse liver microsomes, with 89 ± 6% intact after incubation[1].
NMDA receptor antagonist 9 (90 min at 37 °C) retains high metabolic stability in mouse liver microsomes with NADPH and UDP-GA, with 88% intact after incubation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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분자량 323.43
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화학식 C21H25NO2
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SMILES
OC1=CC=C2C(C[C@@H]([C@@H]2O)N3CCC(CC3)CC4=CC=CC=C4)=C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NMDA receptor antagonist 9 Related Classifications
HY-181007 Related Classifications
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- NMDA receptor antagonist 9
- NMDA receptor antagonist9
- NMDA receptor antagonist-9
- iGluR
- Sigma Receptor
- ischemic stroke
- parkinson’s disease
- GluN2B subunit-containing NMDA receptor
- ifenprodil binding site
- huntington’s disease
- depression
- neuropathic pain
- σ2 receptors
- σ1 receptors
- alzheimer’s disease
- Inhibitor
- inhibitor
- inhibit