PD-168077
Based on 1 publication(s) in Google Scholar
PD-168077 is a selective dopamine D4 receptor agonist, with a Ki of 9 nM.
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- CAS No.: 190383-31-4
- 화학식: C20H22N4O
- 분자량:334.41
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) PD-168077
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
17 nM
Compound: 6
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Agonist activation of human dopamine receptor stimulating mitogenesis in Dopamine receptor D4-transfected CHO pro-5 cells using [3H]thymidine as radioligand
Agonist activation of human dopamine receptor stimulating mitogenesis in Dopamine receptor D4-transfected CHO pro-5 cells using [3H]thymidine as radioligand
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[PMID: 9191952] |
| HEK293 | EC50 |
>10 μM
Compound: 2
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Agonist activity at human recombinant D2 receptor expressed in HEK293 cells by FLIPR assay
Agonist activity at human recombinant D2 receptor expressed in HEK293 cells by FLIPR assay
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[PMID: 16913699] |
| HEK293 | EC50 |
8.3 nM
Compound: 2
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Activity at human recombinant D4.4 receptor expressed in HEK293 cells by FLIPR assay
Activity at human recombinant D4.4 receptor expressed in HEK293 cells by FLIPR assay
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[PMID: 16913699] |
| HEK293 | EC50 |
8.3 nM
Compound: 2, PD-168077
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Agonist activity at human D4.4 receptor in HEK293 cells coexpressing G-alpha-qo5 by FLIPR
Agonist activity at human D4.4 receptor in HEK293 cells coexpressing G-alpha-qo5 by FLIPR
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[PMID: 17149874] |
| HEK293 | IC50 |
>10 μM
Compound: 2
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Antagonist activity at human recombinant D2 receptor expressed in HEK293 cells by FLIPR assay
Antagonist activity at human recombinant D2 receptor expressed in HEK293 cells by FLIPR assay
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[PMID: 16913699] |
In the PD-168077-treated cell, p-CaMKII exhibits a significantly increased clustering at synaptic sites, as indicated by the enhanced colocalization with PSD-95[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 190383-31-4
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분자량 334.41
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화학식 C20H22N4O
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SMILES
O=C(NCN1CCN(C2=CC=CC=C2C#N)CC1)C3=CC=CC(C)=C3
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
순도&문서
References
[1]. Clifford JJ, et al. Topographically based search for an "Ethogram" among a series of novel D(4) dopamine receptor agonists and antagonists. Neuropsychopharmacology. 2000 May;22(5):538-44. [Content Brief]
[2]. Gu Z, et al. Activation of dopamine D4 receptors induces synaptic translocation of Ca2+/calmodulin-dependent protein kinase II in cultured prefrontal cortical neurons. Mol Pharmacol. 2006 Mar;69(3):813-22. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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