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Cat. No.: HY-183965

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PLK3-IN-1

PLK3-IN-1 is a selective Polo-like kinase 3 (PLK3) inhibitor with a human PLK3 IC₅₀ of 5 nM. PLK3-IN-1 can be used for cancer research.

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화학식: C₂₇H₂₉FN₈O
분자량:500.57

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

PLK3-IN-1 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

PLK3-IN-1 is a selective Polo-like kinase 3 (PLK3) inhibitor with a human PLK3 IC₅₀ of 5 nM. PLK3-IN-1 can be used for cancer research^[1].

All Polo-like Kinase (PLK) Isoforms :

In Vitro

PLK3-IN-1 (Compound 9) potently inhibits purified PLK3 with an IC₅₀ of 0.005 μM, and exhibits 1000-fold selectivity over PLK1 and 60-fold selectivity over PLK2 in a biochemical kinase inhibition assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

분자량 500.57
화학식 C₂₇H₂₉FN₈O
SMILES

CN1CCC[C@H](C1)C2=CNC3=CC=C(C=C32)NC4=NC=C(C(N5CCN(C(C5)=O)C6=CC=CC=N6)=N4)F
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Yap JL, et al. Structure-Guided Discovery of Selective Polo-Like Kinase 3 Inhibitors. ACS Med. Chem. Lett. 2026 May 12.

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References

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PLK3-IN-1

All Polo-like Kinase (PLK) Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

PLK3-IN-1 Related Classifications

HY-183965 Related Classifications