PSMA-1092
PSMA-1092 is a fluorescent probe targeting prostate-specific membrane antigen (PSMA). PSMA-1092 binds to PSMA through two Glu-urea-Lys motifs and inhibits its glutamate carboxypeptidase activity, with a human Ki of 80 pM. PSMA-1092 accumulates in PSMA-positive tumors, and co-injection of a PSMA inhibitor reduces tumor signal. PSMA-1092 can be used for research on prostate cancer.
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- CAS No.: 2481214-35-9
- 화학식: C50H62N12O16S2
- 분자량:1151.23
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
IC50 & Target
[1]|
glutamate carboxypeptidase |
PSMA 80 pM (Ki) |
In Vitro
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:LNCaP tumor-bearing mice[1]
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Dosage:2.5 mg/kg
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Administration:tail vein injection; single administration
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Result:Two hours after injection, probe enrichment was visible in the tumor; by 4 hours, the tumor could be clearly distinguished from the surrounding normal tissue.
Chemical Information
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CAS No. 2481214-35-9
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분자량 1151.23
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화학식 C50H62N12O16S2
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SMILES
OC(CC[C@@H](C(O)=O)NC(N[C@H](C(O)=O)CCCCNC(CCN(C1=CC=C(C=C1)C2=C(N=S=N3)C3=C(C4=CC=C(C=C4)N(C)CCC(NCCCC[C@@H](C(O)=O)NC(N[C@H](C(O)=O)CCC(O)=O)=O)=O)C5=NSN=C25)C)=O)=O)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PSMA-1092 Related Classifications
HY-179330 Related Classifications
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