country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-189681

Copy Link Print Information

QLH-11811

QLH-11811 is a mutant-selective EGFR tyrosine kinase inhibitor. QLH-11811 reversibly inhibits EGFR-19del/T790M/C797S and EGFR-L858R/T790M/C797S tyrosine kinase activity (IC₅₀ = 2.6 nM and 3.1 nM, respectively), thereby overcoming C797S-mediated drug resistance. QLH-11811 exhibits weaker inhibitory activity against wild-type EGFR than against mutant EGFR variants. QLH-11811 can be used for research on advanced non-small cell lung cancer.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2595202-02-9
화학식: C₂₉H₃₁BrN₉O₃P
분자량:664.49

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

QLH-11811 Chemical Structure

CAS No.: 2595202-02-9

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All EGFR Isoforms :

In Vitro

QLH-11811 exhibits IC₅₀ values of 2.6 nM and 3.1 nM against EGFR-19del/T790M/C797S-TK and EGFR-L858R/T790M/C797S-TK in Ba/F3 cell lines, respectively, and an IC50 of 61 nM against wild-type EGFR; in A431 cell lines, its IC₅₀ against wild-type EGFR was 440 nM, demonstrating selectivity for mutant EGFR^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 2595202-02-9
분자량 664.49
화학식 C₂₉H₃₁BrN₉O₃P
SMILES

CN1C=C(C=N1)C2=C(C=C(C(NC3=NC=C(C(NC4=CC=C5N=CC=NC5=C4P(C)(C)=O)=N3)Br)=C2)OC)N6CCOCC6
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Kadam VM, et al. Recent advances in synthetic strategies of fourth-generation EGFR tyrosine kinase inhibitors under clinical trials for the treatment of resistant non-small cell lung cancer (NSCLC). Bioorganic chemistry. 2026 Oct 05;181:110353.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기