RFI-641
RFI-641 is a selective inhibitor of the respiratory syncytial virus (RSV), with an IC50 of 50 nM. RFI-641 inhibit binding and fusion of enveloped virus via interaction with the viral fusion protein.
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- CAS No.: 197366-24-8
- 화학식: C58H60N24Na2O22S6
- 분자량:1683.61
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HFF | IC50 |
0.05 μM
Compound: 3 (RF-1461)
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Inhibitory concentration against human respiratory syncytial virus strain A2 in human foreskin fibroblasts
Inhibitory concentration against human respiratory syncytial virus strain A2 in human foreskin fibroblasts
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[PMID: 15603966] |
| HFF | IC50 |
2.55 μM
Compound: 3 (RF-1461)
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Inhibitory concentration against human cytomegalovirus strain Ad169 in human foreskin fibroblasts
Inhibitory concentration against human cytomegalovirus strain Ad169 in human foreskin fibroblasts
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[PMID: 15603966] |
| Vero | IC50 |
7.72 μM
Compound: 3 (RF-1461)
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Inhibitory concentration against herpes simplex 1 strain Patton in vero cells
Inhibitory concentration against herpes simplex 1 strain Patton in vero cells
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[PMID: 15603966] |
Chemical Information
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CAS No. 197366-24-8
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분자량 1683.61
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화학식 C58H60N24Na2O22S6
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SMILES
O=C(CN(S(=O)(C1=CC(NC2=NC(NC3=CC(S(=O)(O[Na])=O)=C(C4=CC=C(NC5=NC(NC6=CC=CC(S(=O)(N(CC(N)=O)CC(N)=O)=O)=C6)=NC(NC7=CC=CC(S(=O)(N(CC(N)=O)CC(N)=O)=O)=C7)=N5)C=C4S(=O)(O[Na])=O)C=C3)=NC(NC8=CC=CC(S(=O)(N(CC(N)=O)CC(N)=O)=O)=C8)=N2)=CC=C1)=O)CC(N)=O)N
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Nikitenko AA, et, al. The discovery of RFI-641 as a potent and selective inhibitor of the respiratory syncytial virus. Bioorg Med Chem Lett. 2001 Apr 23;11(8):1041-4. [Content Brief]
[2]. Razinkov V, et, al. RFI-641 inhibits entry of respiratory syncytial virus via interactions with fusion protein. Chem Biol. 2001 Jul;8(7):645-59. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RFI-641 Related Classifications
HY-19874 Related Classifications
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