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Cat. No.: HY-12730

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RG7109

RG7109 is a non-nucleoside allosteric inhibitor of the hepatitis C virus NS5B polymerase. RG7109 inhibits HCV replication in replicon assays.

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CAS No.: 1257830-82-2
화학식: C₂₇H₂₉N₃O₅S
분자량:507.60

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

RG7109 Chemical Structure

CAS No.: 1257830-82-2

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

RG7109 is a non-nucleoside allosteric inhibitor of the hepatitis C virus NS5B polymerase. RG7109 inhibits HCV replication in replicon assays^[1]^[2].

All DNA/RNA Synthesis Isoforms :

In Vitro

Viral Infection

RG7109 is a potent, equipotent inhibitor of GT-1a H77 and GT-1b Con1 HCV replicons, maintaining potency of ≤10 nM in 40% serum, with serum shifts of 3.8- to 9.4-fold^[1].
RG7109 retains potency against GT-1a and GT-1b NS5B isolates in transient replicon assays, with the greatest reduction in potency observed against the RO-38 isolate containing S556G^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1257830-82-2
분자량 507.60
화학식 C₂₇H₂₉N₃O₅S
SMILES

CS(=O)(NC1=CC=C(C2=CC3=C(OC)C(C(C)(C)C)=CC(C4=CC=C(OC)NC4=O)=C3N=C2)C=C1)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Talamas FX, et al. Discovery of N-[4-[6-tert-butyl-5-methoxy-8-(6-methoxy-2-oxo-1H-pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide (RG7109), a potent inhibitor of the hepatitis C virus NS5B polymerase. Journal of medicinal chemistry. 2014 Mar 13;57(5):1914-31. [Content Brief]

[2]. de la Guardia C, et al. Antiviral Activity of Novel Quinoline Derivatives against Dengue Virus Serotype 2. Molecules (Basel, Switzerland). 2018 Mar 16;23(3):672.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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