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Cat. No.: HY-161885

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SMARCA2/4-IN-4

SMARCA2-IN-6 is a SMARCA2 and SMARCA4 inhibitor, with an IC₅₀ value of <0.005 μM for both SMARCA2 and SMARCA4. SMARCA2-IN-6 exerts anticancer activity against BRG1-mutant melanoma. SMARCA2-IN-6 can be used for research related to Brg1/Smarca4-mutant cancers.

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CAS No.: 2270875-79-9
화학식: C₁₀H₈ClF₂N₅OS
분자량:319.72

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

SMARCA2/4-IN-4 Chemical Structure

CAS No.: 2270875-79-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

SMARCA2

<0.005 μM (IC₅₀)

SMARCA4

<0.005 μM (IC₅₀)

All SWI/SNF Complex Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
SBC-5	EC₅₀	>10 μM Compound: 11	Antiproliferative activity against human SBC5 cells assessed as cell growth inhibition after 6 days by celltiter-glo luminescent cell viability assay Antiproliferative activity against human SBC5 cells assessed as cell growth inhibition after 6 days by celltiter-glo luminescent cell viability assay	[PMID: 30339381]

In Vitro

SMARCA2-IN-6 (Compound 11) potently inhibits the ATPase activity of truncated BRM ATPase−SnAC and BRG1 ATPase−SnAC proteins, with an IC₅₀ of <0.005 μM for both targets^[1].
SMARCA2-IN-6 inhibits the expression of the KRT80 gene in BRG1-mutant H1299 cells, with an AAC₅₀ of 0.026 μM^[1].
SMARCA2-IN-6 potently inhibits the proliferation of BRG1-mutant SKMEL5 cells with an AAC₅₀ of 0.013 μM, while it shows no significant activity in SBC5 cells with BRM-BRG1 target deletion^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2270875-79-9
분자량 319.72
화학식 C₁₀H₈ClF₂N₅OS
SMILES

O=C(NC1=CC(C(F)F)=NS1)NC2=CC(Cl)=NC=C2N
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Papillon JPN, et al. Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers. J Med Chem. 2018;61(22):10155-10172. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

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SMARCA2/4-IN-4

All SWI/SNF Complex Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

SMARCA2/4-IN-4 Related Classifications

HY-161885 Related Classifications