T-1101
Based on 1 publication(s) in Google Scholar
T-1101 (TAI-95) is an orally active inhibitor for mitose regulating highly expressed oncoprotein 1 (Hec1). T-1101 blocks the interaction between Hec1 and NEK2, exhibits cytotoxicity in human liver cancer cells with GI50 of 15-70 nM. T-1101 induces apoptosis in Huh-7. T-1101 exhibits antitumor efficacy in mouse models.
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- CAS No.: 1438638-83-5
- 화학식: C24H23N5O3S2
- 분자량:493.60
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications Citing Use of MedChemExpress (MCE) T-1101
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Biological Activity
|
NEK2 |
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| COLO 205 | GI50 |
29.1 nM
Compound: 9j
|
Antiproliferative activity against human COLO 205 cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay
Antiproliferative activity against human COLO 205 cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay
|
[PMID: 32113126] |
| HeLa | IC50 |
21.1 nM
Compound: 9j
|
Antiproliferative activity against human HeLa cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay
Antiproliferative activity against human HeLa cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay
|
[PMID: 32113126] |
| Huh-7 | GI50 |
34.98 nM
Compound: 9j
|
Antiproliferative activity against human Huh-7 cells by CellTiter 96 Aqueous One Solution Reagent based assay
Antiproliferative activity against human Huh-7 cells by CellTiter 96 Aqueous One Solution Reagent based assay
|
[PMID: 32113126] |
| Huh-7 | GI50 |
59.9 nM
Compound: 9j
|
Anticancer activity against human Huh-7 cells after 24 hrs by CellTiter 96 Aqueous One Solution Reagent based assay
Anticancer activity against human Huh-7 cells after 24 hrs by CellTiter 96 Aqueous One Solution Reagent based assay
|
[PMID: 32113126] |
| K562 | IC50 |
18 nM
Compound: 9j
|
Antiproliferative activity against human K562 cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay
Antiproliferative activity against human K562 cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay
|
[PMID: 32113126] |
| MDA-MB-231 | IC50 |
14.8 nM
Compound: 9j
|
Antiproliferative activity against human MDA-MB-231 cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay
Antiproliferative activity against human MDA-MB-231 cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay
|
[PMID: 32113126] |
| MDA-MB-468 | IC50 |
21.5 nM
Compound: 9j
|
Antiproliferative activity against human MDA-MB-468 cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay
Antiproliferative activity against human MDA-MB-468 cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay
|
[PMID: 32113126] |
| U2OS | GI50 |
83.2 nM
Compound: 9j
|
Antiproliferative activity against human U2OS cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay
Antiproliferative activity against human U2OS cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay
|
[PMID: 32113126] |
| U-937 | GI50 |
12.4 nM
Compound: 9j
|
Antiproliferative activity against human U-937 cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay
Antiproliferative activity against human U-937 cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay
|
[PMID: 32113126] |
Chemical Information
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CAS No. 1438638-83-5
-
분자량 493.60
-
화학식 C24H23N5O3S2
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SMILES
O=C(C1=CC=NC=C1)NC2=NC(C3=C(C)C=C(SC4=NC=C(OCCOC)N=C4)C=C3C)=CS2
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Synonyms
TAI-95
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Cancer Res Commun
Inhibition of NEK2 Promotes Chemosensitivity and Reduces KSHV-positive Primary Effusion Lymphoma Burden. [Abstract]2024 Apr 9;4(4):1024-1040. PMID: 38592451
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)