TNT-i
TNT-i (NPD3064) is an inhibitor targeting M-Sec. TNT-i inhibits M-Sec-induced tunneling nanotube (TNT) formation reversibly. TNT-i reduces wild-type HIV-1 production in macrophages and M-Sec-expressing T cells. TNT-i shows low cytotoxic effects on macrophages and T cells. TNT-i can be used for the research of HIV-1 infection.
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- 화학식: C18H25BrN2O2
- 분자량:381.31
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보관:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
In Vitro
TNT-i (10 μM; 24 h) potently and reversibly inhibits M-Sec-induced TNT formation in GFP-M-Sec-transfected HeLa cells[1].
TNT-i (3-10 μM; 3 days) dose-dependently reduces TNT formation in wild-type HIV-1 JRFL-infected human monocyte-derived macrophages, with a 50% reduction observed after 3 days of incubation[1].
TNT-i (3-10 μM; 3 days) reduces wild-type HIV-1 production by approximately 50% in human monocyte-derived macrophages, with no effect on Nef-deficient HIV-1 production or MDM cell survival[1].
TNT-i (10 μM; 4 days) reduces wild-type HIV-1 production by approximately 50% in M-Sec-positive MT-2 T cells, with no effect on Nef-deficient HIV-1 production or MT-2 cell survival[1].
TNT-i (10 μM; 24 h) does not inhibit Nef-mediated downregulation of cell-surface CD4 or MHC I in 293-CD4 cells, indicating it does not target Nef's core regulatory functions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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분자량 381.31
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화학식 C18H25BrN2O2
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Color White to off-white
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SMILES
CC[C@]1(C2)C[N@@](C(C3=CC(Br)=CC=C3O)[N@@]2C4)C[C@]4(CC)C1O
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Synonyms
NPD3064
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
순도&문서
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TNT-i Related Classifications
HY-157469 Related Classifications
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