Trenimon
Trenimon is a compound with anti-cancer effects. Trenimon shows mutagenic actions in many species by inducing point and chromosomal mutations, sister-chromatid exchanges, recombination phenomena and phage induction. Trenimon can be used for the research of cancer.
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- CAS No.: 68-76-8
- 화학식: C12H13N3O2
- 분자량:231.25
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| K562 | IC50 |
2.9 nM
Compound: 2
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In vitro cytotoxicity tested against human chronic leukemia K562 cells
In vitro cytotoxicity tested against human chronic leukemia K562 cells
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[PMID: 9022802] |
Trenimon (0.17 mM) penetrates readily into mouse lymphoma cells in vitro[1]. Trenimon (0.17 nM; 5 min-16 h) time-denpendently reduces the priming activity of DNA[2]. Trenimon (1 nM-10 μM; 10-20 min) leds HeLa cells death after 2 weeks with a dose of 10 μM and dose-dependently suppresses mitosis in cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BR 46 male rats[4]
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Dosage:0.03 mg/kg
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Administration:Intravenous injection; 0.03 mg/kg once per week for 52 weeks
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Result:Showed an cancerogenic effect and 24% animals developed malign tumors, and showed a induction time of the tumors is 16 months.
Chemical Information
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CAS No. 68-76-8
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분자량 231.25
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화학식 C12H13N3O2
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SMILES
O=C1C(N2CC2)=C(N3CC3)C(C(N4CC4)=C1)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Linford JH. 2,3,5-Tris-ethylenimino-1,4-benzoquinone (Trenimon): some chemical and biological properties. Chem Biol Interact. 1973 Mar;6(3):149-68. [Content Brief]
[2]. GRUNICKE H, et al. THE EFFECTS OF THE ALKYLATING CYTOSTATIC AGENT, 2,3,5-TRISETHYLENEIMINO-BENZOQUINONE-1,4(TRENIMON), ON THE PRIMING ABILITY OF DNA FROM MOUSE-ASCITES-TUMOR CELLS IN THE RNA-POLYMERASE-SYSTEM. Biochem Biophys Res Commun. 1965 Feb 3;18:319 [Content Brief]
[3]. Wegehaupt S, Sehrbundt HJ. Cytologische Untersuchungen an HeLa-Zellen nach kurzfristigen 2,3,5-Trisathyleniminobenzochinon-1,4-Gaben (Trenimon-R) [Cytologic studies on HeLa cells following short-spaced doses of 2,3,5-trisethyleniminobenzoquinone-1,4 (Tren [Content Brief]
[4]. Obe G, Beek B. Trenimon: biochemical, physiological and genetic effects on cells and organisms. Mutat Res. 1979 Mar;65(1):21-70. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Trenimon Related Classifications
HY-105740 Related Classifications
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