Tylogenin
Tylogenin is a Na+/K+ ATPase inhibitor with an IC50 of 93.3 μM against rabbit-derived targets. Tylogenin inhibits antigen-induced mediator release from rabbit basophils and IgE-dependent histamine release from human leukocytes. Tylogenin exhibits antiallergic activity. Tylogenin can be used in research related to allergic diseases.
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- CAS No.: 135247-46-0
- 화학식: C28H38O10
- 분자량:534.60
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
Tylogenin (1-300 μM; 15-120 min) exhibits time-dependent inhibition of antigen-induced serotonin release from sensitized rabbit basophils in the BDSR assay, with an IC50 of 38.90 μM after 120 min of incubation, and the inhibition rate reaches 92% at a concentration of 300 μM following 120 min of incubation[1].
Tylogenin (1-300 μM; 4 h) inhibits antigen-induced Histamine (HY-B1204) release from leukocytes of atopic individuals in the LDHR assay, with an IC50 of 48.98 μM[1].
Tylogenin (5-2000 μM; 1 h) inhibits Na+/K+ ATPase activity in rabbit renal cortical basolateral membrane vesicles, with an IC50 of 93.3 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 135247-46-0
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분자량 534.60
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화학식 C28H38O10
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SMILES
C[C@]12[C@@]([C@H](C(CC2)=O)OC(C)=O)([H])[C@H](C[C@]3([H])[C@]1([H])CC[C@@]([C@@H]3OC(C)=O)(C([C@@](C)(O4)OC)=CC4=O)C)OC(C)=O
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Gnabre, Jean-Noel. Antiallergic activity of Tylophora sylvatica. The University of Arizona.
[2]. Gnabre JN, et al. Antiallergic activity of tylogenin, a novel steroidal compound from Tylophora sylvatica. International journal of immunopharmacology. 1994 Aug;16(8):641-50. [Content Brief]
[3]. Gnabre JN, et al. Tylophora compounds as Na+/K(+)-ATPase inhibitors. Gen Pharmacol. 1993 Sep;24(5):1107-13. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tylogenin Related Classifications
HY-183389 Related Classifications
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