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Cat. No.: HY-165453

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VUF14480

VUF14480 is a partial agonist of histamine H4 (hH4) receptor-mediated G protein signalling and β-arrestin2 recruitment. VUF14480 binds covalently to hH4 receptor (pK_i: 6.3 for hH4-WT receptor). VUF14480 partially induces hH4 receptor-mediated G protein activation and β-arrestin2 recruitment. VUF14480 can be used in the research of inflammatory diseases.

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CAS No.: 1605304-31-1
화학식: C₁₇H₂₀N₄
분자량:280.38

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

VUF14480 Chemical Structure

CAS No.: 1605304-31-1

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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- IC₅₀ & Target
Chemical Information
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Bioz

Biological Activity

제품 설명

IC₅₀ & Target

pK_i: 6.3 for hH4-WT receptor^[1]

All Histamine Receptor Isoforms :

Chemical Information

CAS No. 1605304-31-1
분자량 280.38
화학식 C₁₇H₂₀N₄
SMILES

N=1C(=NC(=CC1C=2C=CC=CC2)N3CCN(C)CC3)C=C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Nijmeijer S, et al. Design and pharmacological characterization of VUF14480, a covalent partial agonist that interacts with cysteine 98(3.36) of the human histamine H₄ receptor. Br J Pharmacol. 2013 Sep;170(1):89-100. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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VUF14480

All Histamine Receptor Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

VUF14480 Related Classifications

HY-165453 Related Classifications