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Cat. No.: HY-162970

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XD23

XD23 is a potent osteosarcoma inhibitor that works by downregulating DKK1 and activating the WNT/β-catenin signaling pathway.

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CAS No.: 2806007-82-7
화학식: C₂₂H₂₆ClN₇O₃
분자량:471.94

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

XD23 Chemical Structure

CAS No.: 2806007-82-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
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Classifications
Bioz

Biological Activity

제품 설명

XD23 is a potent osteosarcoma inhibitor that works by downregulating DKK1 and activating the WNT/β-catenin signaling pathway.

All Wnt Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	IC₅₀	5.2 μM Compound: 14m	Antiproliferative activity against human A-375 cells assessed as inhibition of cell growth measured after 72 hrs by CCK8 assay Antiproliferative activity against human A-375 cells assessed as inhibition of cell growth measured after 72 hrs by CCK8 assay	[PMID: 35797896]
MCF7	IC₅₀	3.15 μM Compound: 14m	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs by CCK8 assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs by CCK8 assay	[PMID: 35797896]
SK-HEP1	IC₅₀	2.04 μM Compound: 14m	Antiproliferative activity against human SK-HEP1 cells assessed as inhibition of cell growth measured after 72 hrs by CCK8 assay Antiproliferative activity against human SK-HEP1 cells assessed as inhibition of cell growth measured after 72 hrs by CCK8 assay	[PMID: 35797896]
SK-MEL-2	IC₅₀	4.79 μM Compound: 14m	Antiproliferative activity against human SK-MEL-2 cells assessed as inhibition of cell growth measured after 72 hrs by CCK8 assay Antiproliferative activity against human SK-MEL-2 cells assessed as inhibition of cell growth measured after 72 hrs by CCK8 assay	[PMID: 35797896]

Chemical Information

CAS No. 2806007-82-7
분자량 471.94
화학식 C₂₂H₂₆ClN₇O₃
SMILES

ClC1=CC=CC(NC(CNC2=CC(N3CCN(C)CC3)=NC(N(C)C(N4C)=O)=C2C4=O)=O)=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. https://www.cell.com/iscience/fulltext/S2589-0042(24)01983-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2589004224019837%3Fshowall%3Dtrue

Calculators

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농도 희석 계산기

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Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

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XD23

All Wnt Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

XD23 Related Classifications

HY-162970 Related Classifications