Lamivudine triphosphate TEA
Based on 1 Customer Validation
Lamivudine triphosphate (3TCTP) TEA is a phosphorylated Lamivudine (HY-B0250) (a nucleoside analogue). Lamivudine triphosphate TEA inhibits the reverse transcriptase of HIV or HBV viruses to block viral replication by chain termination. Lamivudine triphosphate TEA is also an inhibitor of the RdRp activity of the NS5B subunit of the HCV. Lamivudine triphosphate TEA can be incorporated into the nascent RNA by the SARS-CoV-2 RdRp, thus halting mutations in the nascent SARS-CoV-2 RNA.
For research use only. We do not sell to patients.
- Purity: 99.89%
- CAS No.: 2736455-56-2
- Formula: C26H59N6O12P3S
- Molecular Weight:772.77
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Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Lamivudine TEA strongly inhibits the RdRp activity of HCV NS5B[1].
Lamivudine TEA inhibits SARS-CoV-2 RdRp in vitro by incorporating into nascent RNA and causing chain termination or nucleotide mis-incorporation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2736455-56-2
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Appearance Liquid
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Molecular Weight 772.77
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Formula C26H59N6O12P3S
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Color White to off-white
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SMILES
CCN(CC)CC.CCN(CC)CC.CCN(CC)CC.NC(C=CN1[C@@H]2CS[C@H](COP(OP(OP(O)(O)=O)(O)=O)(O)=O)O2)=NC1=O
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Synonyms
3TCTP TEA
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
H2O : 50 mg/mL (64.70 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.2940 mL | 6.4702 mL | 12.9405 mL | 32.3512 mL |
| 5 mM | 0.2588 mL | 1.2940 mL | 2.5881 mL | 6.4702 mL | |
| 10 mM | 0.1294 mL | 0.6470 mL | 1.2940 mL | 3.2351 mL | |
| 15 mM | 0.0863 mL | 0.4313 mL | 0.8627 mL | 2.1567 mL | |
| 20 mM | 0.0647 mL | 0.3235 mL | 0.6470 mL | 1.6176 mL | |
| 25 mM | 0.0518 mL | 0.2588 mL | 0.5176 mL | 1.2940 mL | |
| 30 mM | 0.0431 mL | 0.2157 mL | 0.4313 mL | 1.0784 mL | |
| 40 mM | 0.0324 mL | 0.1618 mL | 0.3235 mL | 0.8088 mL | |
| 50 mM | 0.0259 mL | 0.1294 mL | 0.2588 mL | 0.6470 mL | |
| 60 mM | 0.0216 mL | 0.1078 mL | 0.2157 mL | 0.5392 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Lamivudine triphosphate TEA Related Classifications
HY-131603B Related Classifications
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