2. Anti-infection Others
  3. Reverse Transcriptase HCV HBV SARS-CoV Drug Derivative
  4. Lamivudine triphosphate TEA

Lamivudine triphosphate (3TCTP) TEA is a phosphorylated Lamivudine (HY-B0250) (a nucleoside analogue). Lamivudine triphosphate TEA inhibits the reverse transcriptase of HIV or HBV viruses to block viral replication by chain termination. Lamivudine triphosphate TEA is also an inhibitor of the RdRp activity of the NS5B subunit of the HCV. Lamivudine triphosphate TEA can be incorporated into the nascent RNA by the SARS-CoV-2 RdRp, thus halting mutations in the nascent SARS-CoV-2 RNA.

For research use only. We do not sell to patients.

Lamivudine triphosphate TEA

Lamivudine triphosphate TEA Chemical Structure

CAS No. : 2736455-56-2

Size Price Stock Quantity
500 μg In-stock

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Other Forms of Lamivudine triphosphate TEA:

Lamivudine triphosphate TEA Related Antibodies

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Description

Lamivudine triphosphate (3TCTP) TEA is a phosphorylated Lamivudine (HY-B0250) (a nucleoside analogue). Lamivudine triphosphate TEA inhibits the reverse transcriptase of HIV or HBV viruses to block viral replication by chain termination. Lamivudine triphosphate TEA is also an inhibitor of the RdRp activity of the NS5B subunit of the HCV. Lamivudine triphosphate TEA can be incorporated into the nascent RNA by the SARS-CoV-2 RdRp, thus halting mutations in the nascent SARS-CoV-2 RNA[1].

In Vitro

Lamivudine TEA strongly inhibits the RdRp activity of HCV NS5B[1].
Lamivudine TEA inhibits SARS-CoV-2 RdRp in vitro by incorporating into nascent RNA and causing chain termination or nucleotide mis-incorporation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lamivudine triphosphate TEA Related Antibodies
Molecular Weight

772.77

Formula

C26H59N6O12P3S
CAS No.
Appearance

Liquid

Color

White to off-white

SMILES

CCN(CC)CC.CCN(CC)CC.CCN(CC)CC.NC(C=CN1[C@@H]2CS[C@H](COP(OP(OP(O)(O)=O)(O)=O)(O)=O)O2)=NC1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (64.70 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2940 mL 6.4702 mL 12.9405 mL
5 mM 0.2588 mL 1.2940 mL 2.5881 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.2940 mL 6.4702 mL 12.9405 mL 32.3512 mL
5 mM 0.2588 mL 1.2940 mL 2.5881 mL 6.4702 mL
10 mM 0.1294 mL 0.6470 mL 1.2940 mL 3.2351 mL
15 mM 0.0863 mL 0.4313 mL 0.8627 mL 2.1567 mL
20 mM 0.0647 mL 0.3235 mL 0.6470 mL 1.6176 mL
25 mM 0.0518 mL 0.2588 mL 0.5176 mL 1.2940 mL
30 mM 0.0431 mL 0.2157 mL 0.4313 mL 1.0784 mL
40 mM 0.0324 mL 0.1618 mL 0.3235 mL 0.8088 mL
50 mM 0.0259 mL 0.1294 mL 0.2588 mL 0.6470 mL
60 mM 0.0216 mL 0.1078 mL 0.2157 mL 0.5392 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Lamivudine triphosphate TEA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lamivudine triphosphate2736455-56-23TCTPReverse TranscriptaseHCVHBVSARS-CoVDrug DerivativeHepatitis C virusHepatitis B virusSARS coronavirusDrug derivativeInhibitorinhibitorinhibit

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