LASV-IN-1
Based on 1 Customer Validation
LASV-IN-1 is a Lassa fever virus (LASV) inhibitor. LASV-IN-1 binds with LASV glycoprotein (GP) and promotes virus membrane fusion and infection. LASV-IN-1 can be used for LASV infection research.
For research use only. We do not sell to patients.
- Purity: 99.85%
- CAS No.: 554438-52-7
- Formula: C30H37N3O2
- Molecular Weight:471.63
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
LASV-IN-1 (1 nM-100 μM; 1 h) inhibits transduction by murine leukemia virus (MLV) pseudotyped with the indicated viral glycoproteins with an IC50 value of 1.8 μM[1]. LASV-IN-1 (1 and 10 μM; 1 h) inhibits LAMP1 binding to LASV GP in vitro[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:293T LAMP1 KO cells expressing LASV GP-His and 293T pX459 cells
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Concentration:1 and 10 μM
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Incubation Time:1 hour
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Result:Inhibited the LASV GP binds to LAMP1.
Chemical Information
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CAS No. 554438-52-7
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Appearance Solid
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Molecular Weight 471.63
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Formula C30H37N3O2
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Color White to off-white
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SMILES
O=C(C1(C[C@H](C2)C3)C[C@H]3C[C@H]2C1)NCC(N(CC4)CCN4C(C5=CC=CC=C5)C6=CC=CC=C6)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 25 mg/mL (53.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1203 mL | 10.6015 mL | 21.2031 mL | 53.0077 mL |
| 5 mM | 0.4241 mL | 2.1203 mL | 4.2406 mL | 10.6015 mL | |
| 10 mM | 0.2120 mL | 1.0602 mL | 2.1203 mL | 5.3008 mL | |
| 15 mM | 0.1414 mL | 0.7068 mL | 1.4135 mL | 3.5338 mL | |
| 20 mM | 0.1060 mL | 0.5301 mL | 1.0602 mL | 2.6504 mL | |
| 25 mM | 0.0848 mL | 0.4241 mL | 0.8481 mL | 2.1203 mL | |
| 30 mM | 0.0707 mL | 0.3534 mL | 0.7068 mL | 1.7669 mL | |
| 40 mM | 0.0530 mL | 0.2650 mL | 0.5301 mL | 1.3252 mL | |
| 50 mM | 0.0424 mL | 0.2120 mL | 0.4241 mL | 1.0602 mL |
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