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Cat. No.: HY-189037

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LDH-IN-6

LDH-IN-6 is a dehydrogenase inhibitor with an I₅₀ of 69 µM against lactate dehydrogenase (LDH). LDH-IN-6 also inhibits glyceraldehyde phosphate dehydrogenase (GPDH) (I₅₀ 300 µM), glutamate dehydrogenase (Glu-DH) (I₅₀ 400 μM), and malate dehydrogenase (MDH) (I₅₀ 500 μM). LDH-IN-6 is useful for research on dehydrogenase-related diseases and can also serve as an intermediate for research related to organic synthesis.

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CAS No.: 35975-82-7
화학식: C₁₈H₁₆N₂O₄
분자량:324.33

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

LDH-IN-6 Chemical Structure

CAS No.: 35975-82-7

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
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Biological Activity

제품 설명

In Vitro

LDH-IN-6 (compound 22) inhibits LDH, GPDH, Glu-DH, and MDH, with I₅₀ values of 69-500 µM^[1].
LDH-IN-6 is obtained by reduction of precursor compound 27 under acidic conditions; it can also be converted into candidate irreversible inhibitors of 4 dehydrogenases via acylation with suitable derivatives of PhSO₂F^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 35975-82-7
분자량 324.33
화학식 C₁₈H₁₆N₂O₄
SMILES

O=C(C1=CN(CC2=CC(N)=CC=C2)C3=CC=C(C=C3C1=O)OC)O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Baker B R. Irreversible enzyme inhibitors. 190. Inhibition of some dehydrogenases by 1-substituted-1,4-dihydro-4-quinolone-3-carboxylic acids. Journal of Medicinal Chemistry. 1972;15(3):233-235.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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