Sphingolipids

C24 (2'(S)-Hydroxy) ceramide (d18:1/24:0) is a biochemical reagent.

Safingol hydrochloride is a lyso-sphingolipid PKC (protein kinase C ) inhibitor.

4-Hydroxysphinganine C17 base (D-Ribo-phytosphingosine C17 base), also known as D-ribo-phytosphingosine or PHS, is a crucial compound present in the membranes of fungi, plants, bacteria, marine organisms, and mammalian tissues. It plays a vital role in preserving the structural integrity of membranes, regulating cellular growth, and mediating the heat stress response in yeast. Additionally, PHS serves as a precursor for the synthesis of important lipid mediators such as PHS 1-phosphate, inositol phosphorylceramide, and KRN7000 (the α-anomer of galactosylceramide). Furthermore, this phospholipid promotes keratinocyte differentiation, making it a valuable active ingredient in cosmetic formulations.

DL-threo-Dihydrosphingosine is a extracellular signal-regulated kinase(ERK) signalling cassette inhibitor and is effective against both growth factor- and G-protein-dependent activation of ERK. DL-threo-Dihydrosphingosine inhibits smooth muscle cell proliferation and can be used for study of asthma.

Lactosyl-C18-sphingosine (C18 Lactosyl(β) Ceramide; Lactosyl Sphingosine) is a bioactive sphingolipid that is a form of lactosylceramide but lacks the fatty acyl group. Lysolactosylceramide (1-50 μM) reduces the viability of human neutrophils in a concentration-dependent manner. Unlike lactosylceramide, Lactosyl-C18-sphingosine has no effect on protein synthesis and cell proliferation in cardiomyocytes. Lactosyl-C18-sphingosine is a lysoganglioside GM3.

C14-Dihydroceramide is an ester product.

C18 ((±)-2'-Hydroxy) ceramide ((±)-2'-Hydroxy) cer) (d18:1/18:0) is a bioactive sphingolipid found in the stratum corneum layer of mammalian epidermis. Ceramides maintains the normal hydration levels required for the normal physiological.

Sphingosine (C22-D-erythro-Sphingosine) is a metabolite of sphingolipid and a pro-Apoptotic signaling messenger. Sphingosine induces apoptosis via Caspase-dependent, mitochondria-dependent and lysosomal affinity detergent pathways, downregulates Bcl-2 and Bcl-xL, and truncates Bid and Bax. Sphingosine is used for cancer research.

Sphinganine-1-phosphate (d17:0) is an ester product.

N-Oleoyl sphinganine (C18:1-Dihydro-ceramide) is an ester product.

N-Octadecanoyl-sulfatide is an ester product.

N-Acetylsphingosylphosphorylcholine is an ester product.

C2 Sphingomyelin (d18:1/2:0) is an ester product.

N-Hexanoylsphingosylphosphorylcholine is an ester product.

N-Hexanoyldihydrosphingosine (C6-dihydro-Ceramide (N-hexanoyl-)) is an ester product.

N-Butyroyl-D-sphingosine (N-Butyryl-D-erythro-sphingosine) is an ester product.

C12-Dihydro-ceramide is an ester product.

C30-Ceramide is an ester product.

Lyso-dihydrosphingomyelin (Sphinganyl-1-phosphorylcholine; Dihydrosphingomyelin) is an ester product.

N-Tetracosanoyl-phytosphingosine is an ester product.