2. Anti-infection
  3. Bacterial
  4. LpxH-IN-AZ1

LpxH-IN-AZ1, a sulfonyl piperazine compound, is a potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor. LpxH-IN-AZ1 is a potent inhibitor of Klebsiella pneumoniae LpxH with IC50 of 0.36 μM .

For research use only. We do not sell to patients.

LpxH-IN-AZ1 Chemical Structure

LpxH-IN-AZ1 Chemical Structure

CAS No. : 901260-40-0

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Based on 1 publication(s) in Google Scholar

LpxH-IN-AZ1 Related Antibodies

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Description

LpxH-IN-AZ1, a sulfonyl piperazine compound, is a potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor. LpxH-IN-AZ1 is a potent inhibitor of Klebsiella pneumoniae LpxH with IC50 of 0.36 μM [1].

In Vitro

LpxH-IN-AZ1 displays IC50 values of 0.36 μM against K. pneumoniae LpxH and 0.14 μM against E. coli LpxH, respectively[1].
LpxH-IN-AZ1 (1 μM) inhibits 75% of the activity of K. pneumoniae LpxH and 83% of the activity of E. coli LpxH in the presence of 100 μM UDPDAGn[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LpxH-IN-AZ1 Related Antibodies
Molecular Weight

453.48

Formula

C21H22F3N3O3S
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

CC(N1CCC2=C1C=CC(S(=O)(N3CCN(C4=CC=CC(C(F)(F)F)=C4)CC3)=O)=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (55.13 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2052 mL 11.0258 mL 22.0517 mL
5 mM 0.4410 mL 2.2052 mL 4.4103 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2052 mL 11.0258 mL 22.0517 mL 55.1292 mL
5 mM 0.4410 mL 2.2052 mL 4.4103 mL 11.0258 mL
10 mM 0.2205 mL 1.1026 mL 2.2052 mL 5.5129 mL
15 mM 0.1470 mL 0.7351 mL 1.4701 mL 3.6753 mL
20 mM 0.1103 mL 0.5513 mL 1.1026 mL 2.7565 mL
25 mM 0.0882 mL 0.4410 mL 0.8821 mL 2.2052 mL
30 mM 0.0735 mL 0.3675 mL 0.7351 mL 1.8376 mL
40 mM 0.0551 mL 0.2756 mL 0.5513 mL 1.3782 mL
50 mM 0.0441 mL 0.2205 mL 0.4410 mL 1.1026 mL
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LpxH-IN-AZ1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LpxH-IN-AZ1901260-40-0BacterialSulfonylpiperazineanalogUDP-2,3-diacylglucosaminepyrophosphatehydrolaseLpxHantibioticInhibitorinhibitorinhibit

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