1. Anti-infection
  2. Bacterial
  3. LpxH-IN-AZ1

LpxH-IN-AZ1 

Cat. No.: HY-130836
Handling Instructions

LpxH-IN-AZ1, a sulfonyl piperazine compound, is a potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor. LpxH-IN-AZ1 is a potent inhibitor of Klebsiella pneumoniae LpxH with IC50 of 0.36 μM .

For research use only. We do not sell to patients.

LpxH-IN-AZ1 Chemical Structure

LpxH-IN-AZ1 Chemical Structure

CAS No. : 901260-40-0

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Description

LpxH-IN-AZ1, a sulfonyl piperazine compound, is a potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor. LpxH-IN-AZ1 is a potent inhibitor of Klebsiella pneumoniae LpxH with IC50 of 0.36 μM [1].

In Vitro

LpxH-IN-AZ1 displays IC50 values of 0.36 μM against K. pneumoniae LpxH and 0.14 μM against E. coli LpxH, respectively[1].
LpxH-IN-AZ1 (1 μM) inhibits 75% of the activity of K. pneumoniae LpxH and 83% of the activity of E. coli LpxH in the presence of 100 μM UDPDAGn[1].

Molecular Weight

453.48

Formula

C₂₁H₂₂F₃N₃O₃S

CAS No.

901260-40-0

SMILES

CC(N1CCC2=C1C=CC(S(=O)(N3CCN(C4=CC=CC(C(F)(F)F)=C4)CC3)=O)=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

LpxH-IN-AZ1BacterialSulfonylpiperazineanalogUDP-2,3-diacylglucosaminepyrophosphatehydrolaseLpxHantibioticInhibitorinhibitorinhibit

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