LSD1-IN-36
LSD1-IN-36 is a potent LSD1 inhibitor with an IC50 value of 0.8 nM. LSD1-IN-36 induces apoptosis and arrests the cell cycle. LSD1-IN-36 shows antitumor activity.
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- 分子式: C22H25N3O6S
- 分子量:459.52
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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LSD1 0.8 nM (IC50) |
LSD1-IN-36 (compound 10e) demonstrates significant inhibitory effects across several human tumor cell lines. It shows strong activity against HCT116 cells, MCF-7, A549, and MDA-MB-231, with IC50 values of 0.1 μM, 0.1 μM, 0.3 μM and 0.8 μM, respectively[1].
LSD1-IN-36 (0.125-0.5 μM; 72 hours) exhibits a significant inhibitory effect on the formation of HCT116 clones at all dosing concentrations[1].
LSD1-IN-36 (0.125-0.5 μM; 72 hours) induces apoptosis and arrests the cell cycle[1].
LSD1-IN-36 (0.125-0.5 μM; 72 hours) increases the expression of H3K9me2, H3K9me1, H3K4me2 and H3K4me1 in HCT116[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCT116 cells
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Concentration:0.125 μM, 0.25 μM, 0.5 μM
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Incubation Time:72 hours
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Result:Induced cell apoptosis in HCT116.
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Cell Line:HCT116 cells
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Concentration:0.125 μM, 0.25 μM, 0.5 μM
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Incubation Time:72 hours
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Result:Induced cell apoptosis in HCT116.
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Cell Line:HCT116 cells
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Concentration:0.125 μM, 0.25 μM, 0.5 μM
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Incubation Time:72 hours
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Result:Increased the expression of H3K9me2 and H3K9me1 in HCT116.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female NOD-SCID mice injected with HCT116 cells[1]
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Dosage:60 mg/kg
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Administration:IP; daily; for 3 weeks
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Result:Showed substantial growth inhibition of tumors.
化学情報
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分子量 459.52
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分子式 C22H25N3O6S
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SMILES
CC1COCC(N1S(=O)(C2=CC(C(N/N=C3CCC4=C(C=CC(O)=C4\3)O)=O)=CC=C2)=O)C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
LSD1-IN-36 関連分類
HY-168504 関連分類
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