Mal-PEG2-amide-C2-amide-Phenyl(β-D-glucuronide)-NMT-IN-7
Based on 1 Customer Validation
Mal-PEG2-amide-C2-amide-Phenyl (β-D-glucuronide)-NMT-IN-7 is an drug-linker conjugate for ADC that contains a potent NMT inhibitor (NMT-IN-7), with an IC50 of 2.1 nM against HsNMT1. Mal-PEG2-amide-C2-amide-Phenyl (β-D-glucuronide)-NMT-IN-7 consists of an NMT inhibitor (HY-160945) and a stable cleavable linker (Mal-PEG2-amide-C2-amide-Phenyl (β-D-glucuronide)). Mal-PEG2-amide-C2-amide-Phenyl (β-D-glucuronide)-NMT-IN-7 can be used for ADC synthesis and breast cancer-related research.\n
For research use only. We do not sell to patients.
- Purity: 95.42%
- CAS No.: 3032302-82-9
- Formula: C55H66F2N8O17
- Molecular Weight:1149.15
-
Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
All Drug-Linker Conjugates for ADC Isoforms
More
Biological Activity
Mal-PEG2-amide-C2-amide-Phenyl (β-D-glucuronide)-NMT-IN-7 (Drug Conjugate 2) contains NMT-IN-7 (NMT inhibitor 1), which inhibits HsNMT1 with an IC50 of 2.1 nM and exhibits potent cytotoxicity against SU-DHL-10 human B-cell lymphoma cells with an IC50 of 0.6 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 3032302-82-9
-
Appearance Solid
-
Molecular Weight 1149.15
-
Formula C55H66F2N8O17
-
Color White to off-white
-
SMILES
O=C(C=CC1=O)N1CCOCCOCCC(NCCC(NC(C=C2COC(N(C)CC3=CN=C4N3C=C(C5=C(C(F)=C(C=C5)F)OCCC6=C(C)N(C)N=C6C(O)C(C)(C)C)C=C4)=O)=C(C=C2)O[C@@H]7O[C@@H]([C@H]([C@@H]([C@H]7O)O)O)C(O)=O)=O)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : 100 mg/mL (87.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (274 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.8702 mL | 4.3510 mL | 8.7021 mL | 21.7552 mL |
| 5 mM | 0.1740 mL | 0.8702 mL | 1.7404 mL | 4.3510 mL | |
| 10 mM | 0.0870 mL | 0.4351 mL | 0.8702 mL | 2.1755 mL | |
| 15 mM | 0.0580 mL | 0.2901 mL | 0.5801 mL | 1.4503 mL | |
| 20 mM | 0.0435 mL | 0.2176 mL | 0.4351 mL | 1.0878 mL | |
| 25 mM | 0.0348 mL | 0.1740 mL | 0.3481 mL | 0.8702 mL | |
| 30 mM | 0.0290 mL | 0.1450 mL | 0.2901 mL | 0.7252 mL | |
| 40 mM | 0.0218 mL | 0.1088 mL | 0.2176 mL | 0.5439 mL | |
| 50 mM | 0.0174 mL | 0.0870 mL | 0.1740 mL | 0.4351 mL | |
| 60 mM | 0.0145 mL | 0.0725 mL | 0.1450 mL | 0.3626 mL | |
| 80 mM | 0.0109 mL | 0.0544 mL | 0.1088 mL | 0.2719 mL |
Mal-PEG2-amide-C2-amide-Phenyl(β-D-glucuronide)-NMT-IN-7 Related Classifications
HY-171814 Related Classifications
Powered by Bioz