Mal-PEG2-amide-C2-amide-Phenyl(β-D-glucuronide)-NMT-IN-7

Cat. No.: HY-171814 Purity: 95.42%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Mal-PEG2-amide-C2-amide-Phenyl(β-D-glucuronide)-NMT-IN-7 (Compound DC-2) is a drug-linker conjugate for ADC. Mal-PEG2-amide-C2-amide-Phenyl(β-D-glucuronide)-NMT-IN-7 consists of a NMT inhibitor (HY-160945) and a stable and cleavable linker (Mal-PEG2-amide-C2-amide-Phenyl(β-D-glucuronide)). Mal-PEG2-amide-C2-amide-Phenyl(β-D-glucuronide)-NMT-IN-7 can be used for synthesis of ADCs.

For research use only. We do not sell to patients.

Mal-PEG2-amide-C2-amide-Phenyl(β-D-glucuronide)-NMT-IN-7 Chemical Structure

CAS No. : 3032302-82-9

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Drug-Linker Conjugates for ADC Isoform Specific Products:

View All Isoforms

Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents Dual payloads

Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

1149.15

Formula

C₅₅H₆₆F₂N₈O₁₇

CAS No.

3032302-82-9

Appearance

Solid

Color

White to off-white

SMILES

O=C(C=CC1=O)N1CCOCCOCCC(NCCC(NC(C=C2COC(N(C)CC3=CN=C4N3C=C(C5=C(C(F)=C(C=C5)F)OCCC6=C(C)N(C)N=C6C(O)C(C)(C)C)C=C4)=O)=C(C=C2)O[C@@H]7O[C@@H]([C@H]([C@@H]([C@H]7O)O)O)C(O)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (87.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.8702 mL	4.3510 mL	8.7021 mL
5 mM	0.1740 mL	0.8702 mL	1.7404 mL
10 mM	0.0870 mL	0.4351 mL	0.8702 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 95.42%

Select Batch:

Data Sheet (271 KB) SDS (252 KB)

COA (252 KB) HNMR (302 KB) RP-HPLC (217 KB) MS (73 KB)

Handling Instructions (2659 KB)

References

[1]. Robin C, et al. Antibody drug conjugate comprising nmt inhibitor and its use. WO2024052684A1. 2024-03-14.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.8702 mL	4.3510 mL	8.7021 mL	21.7552 mL
	5 mM	0.1740 mL	0.8702 mL	1.7404 mL	4.3510 mL
	10 mM	0.0870 mL	0.4351 mL	0.8702 mL	2.1755 mL
	15 mM	0.0580 mL	0.2901 mL	0.5801 mL	1.4503 mL
	20 mM	0.0435 mL	0.2176 mL	0.4351 mL	1.0878 mL
	25 mM	0.0348 mL	0.1740 mL	0.3481 mL	0.8702 mL
	30 mM	0.0290 mL	0.1450 mL	0.2901 mL	0.7252 mL
	40 mM	0.0218 mL	0.1088 mL	0.2176 mL	0.5439 mL
	50 mM	0.0174 mL	0.0870 mL	0.1740 mL	0.4351 mL
	60 mM	0.0145 mL	0.0725 mL	0.1450 mL	0.3626 mL
	80 mM	0.0109 mL	0.0544 mL	0.1088 mL	0.2719 mL