Mal-PEG8-Val-Ala-Exatecan

Cat. No.: HY-176766 Purity: 99.55%: Data Sheet
COA

SDS
Handling Instructions
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Mal-PEG8-Val-Ala-Exatecan (Compound 1033) is a Drug-Linker Conjugates for ADC, which is composed of Exatecan (HY-13631) and a linker. Mal-PEG8-Val-Ala-Exatecan can be used for ADC synthesis.

For research use only. We do not sell to patients.

Mal-PEG8-Val-Ala-Exatecan Chemical Structure

CAS No. : 3025787-70-3

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	Get quote
200 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Purity & Documentation
References
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Description

Mal-PEG8-Val-Ala-Exatecan (Compound 1033) is a Drug-Linker Conjugates for ADC, which is composed of Exatecan (HY-13631) and a linker. Mal-PEG8-Val-Ala-Exatecan can be used for ADC synthesis^[1].

Molecular Weight

1180.27

Formula

C₅₈H₇₈FN₇O₁₈

CAS No.

3025787-70-3

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=C5C6=C(CC[C@@H]5NC([C@H](C)NC([C@H](C(C)C)NC(CCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCN7C(C=CC7=O)=O)=O)=O)=O)=O)C(C)=C(F)C=C6N=C4C3=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (84.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.8473 mL	4.2363 mL	8.4726 mL
5 mM	0.1695 mL	0.8473 mL	1.6945 mL
10 mM	0.0847 mL	0.4236 mL	0.8473 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.55%

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Data Sheet (272 KB) SDS (252 KB)

COA (255 KB) HNMR (176 KB) RP-HPLC (232 KB) LCMS (97 KB)

Handling Instructions (2659 KB)

References

[1]. Jaume Pons, et al. Exatecan derivatives and antibody-drug conjugates thereof. Patent. WO2024098066

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.8473 mL	4.2363 mL	8.4726 mL	21.1816 mL
	5 mM	0.1695 mL	0.8473 mL	1.6945 mL	4.2363 mL
	10 mM	0.0847 mL	0.4236 mL	0.8473 mL	2.1182 mL
	15 mM	0.0565 mL	0.2824 mL	0.5648 mL	1.4121 mL
	20 mM	0.0424 mL	0.2118 mL	0.4236 mL	1.0591 mL
	25 mM	0.0339 mL	0.1695 mL	0.3389 mL	0.8473 mL
	30 mM	0.0282 mL	0.1412 mL	0.2824 mL	0.7061 mL
	40 mM	0.0212 mL	0.1059 mL	0.2118 mL	0.5295 mL
	50 mM	0.0169 mL	0.0847 mL	0.1695 mL	0.4236 mL
	60 mM	0.0141 mL	0.0706 mL	0.1412 mL	0.3530 mL
	80 mM	0.0106 mL	0.0530 mL	0.1059 mL	0.2648 mL