Mbarraxanthone
Mbarraxanthone (1,3,7-Trihydroxy-4-prenylxanthone) is a prenylated trioxygenated xanthone. Mbarraxanthone exhibits inhibitory activity against Gram-positive and Gram-negative bacteria, and inhibits lipopolysaccharide-induced nitric oxide (NO) production in macrophages. Mbarraxanthone can be used in research on bacterial infections.
For research use only. We do not sell to patients.
- CAS No.: 14211-38-2
- Formula: C18H16O5
- Molecular Weight:312.32
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| RAW264.7 | IC50 |
27.1 μM
|
Inhibition of lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages.
Inhibition of lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages.
|
22582907 |
In Vitro
Mbarraxanthone is isolated from Symphonia globulifera L. heartwood and identified as 4-(3,3-dimethylallyl)-1,3,7-trihydroxyxanthone (IVa), with its dimethyl ether derivative (IVb) characterized by a molecular weight of 340 and a 1,3,7-trioxygenated xanthone UV absorption pattern[3].
1,3,7-Trihydroxy-4-prenylxanthone (compound 3) inhibits lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages with an IC50 of 27.1 μM[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
-
CAS No. 14211-38-2
-
Molecular Weight 312.32
-
Formula C18H16O5
-
SMILES
O=C1C2=CC(O)=CC=C2OC3=C(C/C=C(C)/C)C(O)=CC(O)=C31
-
Synonyms
1,3,7-Trihydroxy-4-prenylxanthone
-
Structure Classification
-
Initial Source
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
-
Gram Staining of Tissue Sections
Gram staining of tissue sections is a histochemical technique used to differentiate Gram-positive and Gram-negative bacteria within histological specimens based on differences in bacterial cell wall structure and dye retention, adapted from classical bacteriological Gram staining into tissue-compatible “histological Gram stain” variants. In tissue applications, modifications of the Brown-Hopps and Brown-Brenn methods are commonly used to improve differentiation of microorganisms embedded within host connective tissue and to reduce overstaining or loss of Gram-negative signal, which are known limitations of earlier approaches. The principle relies on crystal violet-iodine complex retention in Gram-positive organisms and subsequent decolorization and counterstaining steps that allow contrast visualization of Gram-negative organisms against tissue background.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Mbarraxanthone Related Classifications
HY-N22069 Related Classifications
Powered by Bioz
Keywords
- Mbarraxanthone
- 14211-38-2
- 1,3,7-Trihydroxy-4-prenylxanthone
- NO Synthase
- RAW 264.7 macrophages
- 5-methoxysalicylic acid
- Symphonia globulifera
- bacterial infections
- phloroglucinol
- Cudrania cochinchinensis
- macrophages
- Gram-negative
- lipopolysaccharide-induced nitric oxide production
- Gram-positive
- Inhibitor
- inhibitor
- inhibit