Metallo β-lactamase ligand 1

Name: Metallo β-lactamase ligand 1
Brand: MedChemExpress
SKU: HY-136306
Rating: 4.5 (1 reviews)

Cat. No.: HY-136306 Pureza: 99.23%: Ficha de datos
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Metallo-beta-lactamase ligand 1 is a class B β-lactamase inhibitor with antibacterial activity extracted from patent WO2019221122A1, compound A.

Para uso exclusivo en investigación. No vendemos a pacientes.

Metallo β-lactamase ligand 1 Estructura química

No. CAS : 1087784-71-1

Tamaño	Stock	Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	Obtener un presupuesto
100 mg	Obtener un presupuesto

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Revisión del cliente

Based on 1 publication(s) in Google Scholar

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Metallo-β-lactamase (MBL) Serine β-lactamase (SBL)

Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn

Metallo-beta-lactamase ligand 1 is a class B β-lactamase inhibitor with antibacterial activity extracted from patent WO2019221122A1, compound A^[1].

In Vitro

One effective measure against β-lactam antibacterial resistant bacteria is to use an inhibitor of β-lactamase, the enzyme responsible for its resistance mechanism, together with an appropriate β-lactam antibacterial agent^[1].
The toxicity of Metallo-beta-lactamase ligand 1 (Compound A) is extremely low in HeLa cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

After infecting mice with an experimental strain (E. coli strain into which a plasmid encoding class B β-lactamase (IMP-1) is introduced), Metallo-beta-lactamase ligand 1 (compound A; 100 mg/kg; intraperitoneal injection) is administered, and life and death are observed. Administration of Metallo-beta-lactamase ligand 1 (compound A) significantly improves the survival rate^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

219.22

Fòrmula

C₇H₉NO₅S

No. CAS

1087784-71-1

Appearance

Solid

Color

Light yellow to light brown

SMILES

CC1=C(S(=O)(N)=O)C(C(O)=O)=C(C)O1

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvente y solubilidad

In Vitro:

DMSO : 250 mg/mL (1140.41 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.5616 mL	22.8081 mL	45.6163 mL
5 mM	0.9123 mL	4.5616 mL	9.1233 mL
10 mM	0.4562 mL	2.2808 mL	4.5616 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Pureza y Documentación

Purity: 99.23%

Select Batch:

Ficha de datos (278 KB) SDS (394 KB)

COA (259 KB) HNMR (250 KB) LCMS (103 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Arakawa, Yoshichika, et al.β-LACTAMASE INHIBITOR. WO2019221122A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.5616 mL	22.8081 mL	45.6163 mL	114.0407 mL
	5 mM	0.9123 mL	4.5616 mL	9.1233 mL	22.8081 mL
	10 mM	0.4562 mL	2.2808 mL	4.5616 mL	11.4041 mL
	15 mM	0.3041 mL	1.5205 mL	3.0411 mL	7.6027 mL
	20 mM	0.2281 mL	1.1404 mL	2.2808 mL	5.7020 mL
	25 mM	0.1825 mL	0.9123 mL	1.8247 mL	4.5616 mL
	30 mM	0.1521 mL	0.7603 mL	1.5205 mL	3.8014 mL
	40 mM	0.1140 mL	0.5702 mL	1.1404 mL	2.8510 mL
	50 mM	0.0912 mL	0.4562 mL	0.9123 mL	2.2808 mL
	60 mM	0.0760 mL	0.3801 mL	0.7603 mL	1.9007 mL
	80 mM	0.0570 mL	0.2851 mL	0.5702 mL	1.4255 mL
	100 mM	0.0456 mL	0.2281 mL	0.4562 mL	1.1404 mL