Art. -Nr.: HY-101006

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Methyl 2,5-dihydroxycinnamate

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Methyl 2,5-dihydroxycinnamate is an erbstatin analog and a stable, potent inhibitor of EGFR kinase activity.

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Reinheit: 99.77%
CAS. Nr.: 63177-57-1
Formel: C₁₀H₁₀O₄
Molecular Weight:194.18

Speicherung:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Methyl 2,5-dihydroxycinnamate Chemical Structure

CAS. Nr.: 63177-57-1

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Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Methyl 2,5-dihydroxycinnamate is an erbstatin analog and a stable, potent inhibitor of EGFR kinase activity^[1].

Alle EGFR Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
A-431	IC₅₀	0.15 μg/mL Compound: 4d	Inhibitory concentration required against A 431 human epidermoid carcinoma cell line Inhibitory concentration required against A 431 human epidermoid carcinoma cell line	[PMID: 11354370]
A549	IC₅₀	4.14 μM Compound: 4	Cytotoxicity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 30615450]
A549	IC₅₀	7.81 μg/mL Compound: 4d	Inhibitory concentration required against A 549 lung cancer cell line Inhibitory concentration required against A 549 lung cancer cell line	[PMID: 11354370]
ACHN	IC₅₀	0.73 μg/mL Compound: 4d	Inhibitory concentration required against ACHN renal cancer cell line Inhibitory concentration required against ACHN renal cancer cell line	[PMID: 11354370]
B16	IC₅₀	0.12 μg/mL Compound: 4d	Inhibitory concentration against B16 murine melanoma cell line Inhibitory concentration against B16 murine melanoma cell line	[PMID: 11354370]
COLO 205	IC₅₀	0.97 μg/mL Compound: 4d	Inhibitory concentration required against COLO 205 colon cancer cell line Inhibitory concentration required against COLO 205 colon cancer cell line	[PMID: 11354370]
DLD-1	IC₅₀	0.68 μg/mL Compound: 4d	Inhibitory concentration required against DLD-1 colon cancer cell line Inhibitory concentration required against DLD-1 colon cancer cell line	[PMID: 11354370]
HaCaT	IC₅₀	9.69 μM Compound: 4	Cytotoxicity against human HaCaT cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human HaCaT cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 30615450]
HCC 2998	IC₅₀	5.22 μg/mL Compound: 4d	Inhibitory concentration required against HCC2998 colon cancer cell line Inhibitory concentration required against HCC2998 colon cancer cell line	[PMID: 11354370]
HCT-116	IC₅₀	0.17 μg/mL Compound: 4d	Inhibitory concentration against HCT 116 human colon cancer cell line Inhibitory concentration against HCT 116 human colon cancer cell line	[PMID: 11354370]
HCT-15	IC₅₀	0.27 μg/mL Compound: 4d	Inhibitory concentration required against HCT 15 colon cancer cell line Inhibitory concentration required against HCT 15 colon cancer cell line	[PMID: 11354370]
HeLa	IC₅₀	8.51 μM Compound: 4	Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 30615450]
HT-29	IC₅₀	1.1 μg/mL Compound: 4d	Inhibitory concentration required against HT 29 colon cancer cell line Inhibitory concentration required against HT 29 colon cancer cell line	[PMID: 11354370]
LOX IMVI	IC₅₀	0.28 μg/mL Compound: 4d	Inhibitory concentration required against LOX-IMVI melanoma cell line Inhibitory concentration required against LOX-IMVI melanoma cell line	[PMID: 11354370]
MCF7	IC₅₀	0.37 μg/mL Compound: 4d	Inhibitory concentration required against MCF-7 breast cancer cell line Inhibitory concentration required against MCF-7 breast cancer cell line	[PMID: 11354370]
MDA-MB-231	IC₅₀	0.82 μg/mL Compound: 4d	Inhibitory concentration required against MDA-MB-231 breast cancer cell line Inhibitory concentration required against MDA-MB-231 breast cancer cell line	[PMID: 11354370]
NCI-H23	IC₅₀	0.93 μg/mL Compound: 4d	Inhibitory concentration required against NCI-H23 lung cancer cell line Inhibitory concentration required against NCI-H23 lung cancer cell line	[PMID: 11354370]
NCI-H460	IC₅₀	3.77 μM Compound: 4	Cytotoxicity against human NCI-H460 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human NCI-H460 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 30615450]
NCI-H661	IC₅₀	4.19 μM Compound: 4	Cytotoxicity against human NCI-H661 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human NCI-H661 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 30615450]
PC-3	IC₅₀	0.42 μg/mL Compound: 4d	Inhibitory concentration required against PC-3 prostate cancer cell line Inhibitory concentration required against PC-3 prostate cancer cell line	[PMID: 11354370]
SNB-19	IC₅₀	2.59 μg/mL Compound: 4d	Inhibitory concentration required against SNB19 CNS cancer cell line Inhibitory concentration required against SNB19 CNS cancer cell line	[PMID: 11354370]
SW-620	IC₅₀	0.39 μg/mL Compound: 4d	Inhibitory concentration required against SW620 colon cancer cell line Inhibitory concentration required against SW620 colon cancer cell line	[PMID: 11354370]
UACC-62	IC₅₀	0.56 μg/mL Compound: 4d	Inhibitory concentration required against UACC62 melanoma cell line Inhibitory concentration required against UACC62 melanoma cell line	[PMID: 11354370]

Chemical Information

CAS. Nr. 63177-57-1
Appearance Solid
Molecular Weight 194.18
Formel C₁₀H₁₀O₄
Color Light brown to brown
SMILES

O=C(OC)/C=C/C1=CC(O)=CC=C1O
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 125 mg/mL (643.73 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

5.1499 mL

25.7493 mL

51.4986 mL

5 mM

1.0300 mL

5.1499 mL

10.2997 mL

10 mM

0.5150 mL

2.5749 mL

5.1499 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Umezawa K, et al. Inhibition of epidermal growth factor-induced DNA synthesis by tyrosine kinase inhibitors. FEBS Lett. 1990 Jan 29;260(2):198-200. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	5.1499 mL	25.7493 mL	51.4986 mL	128.7465 mL
	5 mM	1.0300 mL	5.1499 mL	10.2997 mL	25.7493 mL
	10 mM	0.5150 mL	2.5749 mL	5.1499 mL	12.8747 mL
	15 mM	0.3433 mL	1.7166 mL	3.4332 mL	8.5831 mL
	20 mM	0.2575 mL	1.2875 mL	2.5749 mL	6.4373 mL
	25 mM	0.2060 mL	1.0300 mL	2.0599 mL	5.1499 mL
	30 mM	0.1717 mL	0.8583 mL	1.7166 mL	4.2916 mL
	40 mM	0.1287 mL	0.6437 mL	1.2875 mL	3.2187 mL
	50 mM	0.1030 mL	0.5150 mL	1.0300 mL	2.5749 mL
	60 mM	0.0858 mL	0.4292 mL	0.8583 mL	2.1458 mL
	80 mM	0.0644 mL	0.3219 mL	0.6437 mL	1.6093 mL
	100 mM	0.0515 mL	0.2575 mL	0.5150 mL	1.2875 mL

Keywords

Methyl 2,5-dihydroxycinnamate

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Methyl 2,5-dihydroxycinnamate

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Anti-Cancer Compound Library

Alle EGFR Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Methyl 2,5-dihydroxycinnamate

Differentiation Inducing Compound Library

Anti-Hepatitis C Virus Compound Library

Anti-Lung Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Obesity Compound Library

Angiogenesis-Related Compound Library

Anti-Liver Cancer Compound Library

Anti-Colorectal Cancer Compound Library

Human Metabolite Library

Anti-Prostate Cancer Compound Library

Cancer Stem Cells Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Cytokine Inhibitors Library

Anti-Ovarian Cancer Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product-like Compound Library

Bioactive Compound Library

Anti-Brain Cancer Compound Library

Protein Kinase Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

Posttranslational Modification Library

Natural Product and Natural Product-Like Compound Library

Immunology/Inflammation Compound Library

JAK/STAT Compound Library

Kinase Inhibitor Library

Protein Tyrosine Kinase Compound Library

Anti-Cancer Compound Library

Alle EGFR Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Methyl 2,5-dihydroxycinnamate Related Classifications

HY-101006 Related Classifications