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Cat. No.: HY-187087

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Methyl O-methylpodocarpate

Methyl O-methylpodocarpate is an influenza A virus (H1N1) inhibitor with activity against H1N1 strains resistant to Oseltamivir and Amantadine, with an EC₅₀ of 0.73 μM. Methyl O-methylpodocarpate blocks viral membrane fusion by targeting hemagglutinin (HA). Methyl O-methylpodocarpate shows only weak activity against the H3N2 subtype and exhibits no significant cytotoxicity to MDCK cells. Methyl O-methylpodocarpate can be used in studies related to H1N1 infection.

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CAS No.: 1231-74-9
화학식: C₁₉H₂₆O₃
분자량:302.41

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Methyl O-methylpodocarpate Chemical Structure

CAS No.: 1231-74-9

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
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Biological Activity

제품 설명

Cellular Effect

Cell Line	Type	Value	Description	References
MDCK	CC₅₀	>40 μM	Cytotoxicity against Madin-Darby canine kidney (MDCK) cells, with CC₅₀ greater than 40 μM as no cytotoxicity was observed at concentrations up to 40 μM. Cytotoxicity against Madin-Darby canine kidney (MDCK) cells, with CC₅₀ greater than 40 μM as no cytotoxicity was observed at concentrations up to 40 μM.	25815159

In Vitro

Methyl O-methylpodocarpate (compound 21) inhibits the infection of MDCK cells by the oseltamivir- and amantadine-resistant influenza A virus strain A/Puerto Rico/8/34 (H1N1), with an EC₅₀ value of 0.73 μM. It exhibits only weak activity against influenza A virus strain A/Hong Kong/8/68 (H3N2) and shows no cytotoxicity toward MDCK cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1231-74-9
분자량 302.41
화학식 C₁₉H₂₆O₃
SMILES

C[C@@]12[C@]([C@](C(OC)=O)(C)CCC1)(CCC=3C2=CC(OC)=CC3)[H]
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Dang Z, et al. Phenolic diterpenoid derivatives as anti-influenza a virus agents. ACS medicinal chemistry letters. 2015 Mar 12;6(3):355-8. [Content Brief]

[2]. Kapahi P, et al. Modulators of alpha-dicarbonyl detoxification and their use for the treatment of diabetic pathologies: U.S. Patent Application 15/648,318[P]. 2018-1-18.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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