Methyl O-methylpodocarpate
Methyl O-methylpodocarpate is an influenza A virus (H1N1) inhibitor with activity against H1N1 strains resistant to Oseltamivir and Amantadine, with an EC50 of 0.73 μM. Methyl O-methylpodocarpate blocks viral membrane fusion by targeting hemagglutinin (HA). Methyl O-methylpodocarpate shows only weak activity against the H3N2 subtype and exhibits no significant cytotoxicity to MDCK cells. Methyl O-methylpodocarpate can be used in studies related to H1N1 infection.
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- No. CAS: 1231-74-9
- Fòrmula: C19H26O3
- Peso molecular:302.41
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDCK | CC50 |
>40 μM
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Cytotoxicity against Madin-Darby canine kidney (MDCK) cells, with CC50 greater than 40 μM as no cytotoxicity was observed at concentrations up to 40 μM.
Cytotoxicity against Madin-Darby canine kidney (MDCK) cells, with CC50 greater than 40 μM as no cytotoxicity was observed at concentrations up to 40 μM.
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25815159 |
| MDCK | EC50 |
0.73 μM
Compound: 20
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Antiviral activity against oseltamivir/amantadine-resistant Influenza A virus (A/Puerto Rico/8/1934(H1N1)) infected in MDCK cells assessed as protection against virus-induced cytocidal effect after 48 hrs by CellTiter-Glo assay
Antiviral activity against oseltamivir/amantadine-resistant Influenza A virus (A/Puerto Rico/8/1934(H1N1)) infected in MDCK cells assessed as protection against virus-induced cytocidal effect after 48 hrs by CellTiter-Glo assay
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[PMID: 25815159] |
| MDCK | CC50 |
40 μM
Compound: 20
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Cytotoxicity against MDCK cells assessed as reduction of cell viability
Cytotoxicity against MDCK cells assessed as reduction of cell viability
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[PMID: 25815159] |
In Vitro
Methyl O-methylpodocarpate (compound 21) inhibits the infection of MDCK cells by the oseltamivir- and amantadine-resistant influenza A virus strain A/Puerto Rico/8/34 (H1N1), with an EC50 value of 0.73 μM. It exhibits only weak activity against influenza A virus strain A/Hong Kong/8/68 (H3N2) and shows no cytotoxicity toward MDCK cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 1231-74-9
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Peso molecular 302.41
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Fòrmula C19H26O3
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SMILES
C[C@@]12[C@]([C@](C(OC)=O)(C)CCC1)(CCC=3C2=CC(OC)=CC3)[H]
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Methyl O-methylpodocarpate Related Classifications
HY-187087 Related Classifications
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Keywords
- Methyl O-methylpodocarpate
- 1231-74-9
- Influenza Virus
- epithelial cells
- MDCK cells
- influenza A virus hemagglutinin
- influenza A/Puerto Rico/8/34 (H1N1)
- hemagglutinin-mediated membrane fusion
- amantadine-resistant H1N1 strains
- oseltamivir-resistant H1N1 strains
- influenza A/Hong Kong/8/68 (H3N2) virus
- Inhibitor
- inhibitor
- inhibit