2. Anti-infection
  3. HIV Influenza Virus
  4. ML416

ML416 is a broad-spectrum antiviral agent. ML416 inhibits host de novo pyrimidine biosynthesis, and induces a variety of interferon-stimulated genes (ISGs). ML416 can be used for the research of viral infections including alphaviruses, influenza virus, and HIV-1.

For research use only. We do not sell to patients.

ML416

ML416 Chemical Structure

CAS No. : 2043014-84-0

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ML416 Related Antibodies

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Description

ML416 is a broad-spectrum antiviral agent. ML416 inhibits host de novo pyrimidine biosynthesis, and induces a variety of interferon-stimulated genes (ISGs). ML416 can be used for the research of viral infections including alphaviruses, influenza virus, and HIV-1[1][2].

IC50 & Target[1]

HIV-1

 

In Vitro

ML416 (Compound 1) (10 μM; 24 h) potently inhibits HIV-1 infectivity in TZM-bl cells, achieving 94% inhibition at a 10 μM concentration[1].
ML416 (1 μM; 2 h pretreatment + 18 h post-infection incubation) potently inhibits V3526-luc and pVSV-luc replication in HEK 293T cells, and its antiviral activity is reversed by exogenous pyrimidines (cytidine, uridine), confirming its mechanism of action involves inhibition of pyrimidine biosynthesis[1].
ML416 (48-96 h) shows low cytotoxicity against Vero 76 cells, with CC50 values ranging from 31.0 to 74.1 μM across 48 to 96 hours of exposure[1].
ML416 (5 μM; 8 h pre-treatment) reduces progeny virus titers by 1.3 to 4.768 log at 5 μM in Vero 76 cells across a broad range of viruses[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ML416 Related Antibodies
Molecular Weight

310.41

Formula

C14H15FN2OS2
CAS No.
SMILES

O=C(N(C1=NC2=C(S1)CCCC2)C)CC=3SC=CC3F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ML416 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ML4162043014-84-0ML 416ML-416HIVInfluenza VirusHuman immunodeficiency virusherpes simplex virus 2orotic acidmouse cellsuridinede novo pyrimidine biosynthesisalphavirusesinterferon-stimulated genesinnate immunity genesdihydroorotic acidtype 1 interferonInhibitorinhibitorinhibit

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