2. JAK/STAT Signaling Stem Cell/Wnt
  3. STAT
  4. MM-206

MM-206, a STAT3 activity inhibitor, potently inhibits the STAT3 SH2 domain-phosphopeptide interaction with IC50 of 1.2 μM. MM-206 demonstrates dose-dependent induction of apoptosis in acute myeloid leukemia (AML) cell lines.

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MM-206

MM-206 構造式

CAS 番号 : 1809581-87-0

容量 価格（税別） 在庫状況 数量
5 mg $231 在庫あり
10 mg $370 在庫あり
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100 mg   お問い合わせ  

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Based on 1 publication(s) in Google Scholar

MM-206 関連抗体

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STAT アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
STAT3 STAT5 STAT6 STAT1

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製品説明

MM-206, a STAT3 activity inhibitor, potently inhibits the STAT3 SH2 domain-phosphopeptide interaction with IC50 of 1.2 μM. MM-206 demonstrates dose-dependent induction of apoptosis in acute myeloid leukemia (AML) cell lines[1].

分子量

497.46

分子式

C22H12F5NO3S2
CAS 番号
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=S(C1=C(C(F)=C(C(F)=C1F)F)F)(NC2=C3C=CC=CC3=C(C(SC4=CC=CC=C4)=C2)O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMF : 25 mg/mL (50.26 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0102 mL 10.0511 mL 20.1021 mL
5 mM 0.4020 mL 2.0102 mL 4.0204 mL
10 mM 0.2010 mL 1.0051 mL 2.0102 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

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体積 （終了）

V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション

純度: 99.9%

COA (258 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMF 1 mM 2.0102 mL 10.0511 mL 20.1021 mL 50.2553 mL
5 mM 0.4020 mL 2.0102 mL 4.0204 mL 10.0511 mL
10 mM 0.2010 mL 1.0051 mL 2.0102 mL 5.0255 mL
15 mM 0.1340 mL 0.6701 mL 1.3401 mL 3.3504 mL
20 mM 0.1005 mL 0.5026 mL 1.0051 mL 2.5128 mL
25 mM 0.0804 mL 0.4020 mL 0.8041 mL 2.0102 mL
30 mM 0.0670 mL 0.3350 mL 0.6701 mL 1.6752 mL
40 mM 0.0503 mL 0.2513 mL 0.5026 mL 1.2564 mL
50 mM 0.0402 mL 0.2010 mL 0.4020 mL 1.0051 mL
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MM-206 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MM-2061809581-87-0MM206MM 206STATSTAT3 inhibitorSTAT3 SH2 domain-phosphopeptide interactionacute myeloid leukemiaInhibitorinhibitorinhibit

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製品名:
MM-206
製品番号:
HY-121725
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