MNK/PIM-IN-1
MNK/PIM-IN-1 represents an innovative dual MNK/PIM inhibitor with a good pharmacokinetic profile.
For research use only. We do not sell to patients.
- CAS No.: 2430792-91-7
- Formula: C27H27FN6O2
- Molecular Weight:486.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HL-60 | GI50 |
1.5 μM
Compound: 21o
|
Antiproliferative activity against human HL-60 cells assessed as reduction of cell viability incubated for 72 hrs by trypan blue staining based cell counting analysis
Antiproliferative activity against human HL-60 cells assessed as reduction of cell viability incubated for 72 hrs by trypan blue staining based cell counting analysis
|
[PMID: 34515481] |
| K562 | GI50 |
2.19 μM
Compound: 21o
|
Antiproliferative activity against human K562 cells assessed as reduction of cell viability incubated for 72 hrs by trypan blue staining based cell counting analysis
Antiproliferative activity against human K562 cells assessed as reduction of cell viability incubated for 72 hrs by trypan blue staining based cell counting analysis
|
[PMID: 34515481] |
| MOLM-13 | GI50 |
1.23 μM
Compound: 21o
|
Antiproliferative activity against human MOLM13 cells assessed as reduction of cell viability incubated for 72 hrs by trypan blue staining based cell counting analysis
Antiproliferative activity against human MOLM13 cells assessed as reduction of cell viability incubated for 72 hrs by trypan blue staining based cell counting analysis
|
[PMID: 34515481] |
Chemical Information
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CAS No. 2430792-91-7
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Molecular Weight 486.54
-
Formula C27H27FN6O2
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SMILES
O=C(C1=CC=C(C2=NC3=C(NC4=CC=C(F)C=C4OC(C)C)N=CN=C3C=C2)C=C1)N5CCNCC5
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)