Monoethyl fumarate
Based on 2 publication(s) in Google Scholar
Monoethyl fumarate is the monoethyl ester form of Fumaric acid (HY-W015883). Monoethyl fumarate is the activator for Nrf2. Monoethyl fumarate is a kind of effective preservative and polymerization agent for macromolecular material.
For research use only. We do not sell to patients.
- Purity: 99.88%
- CAS No.: 2459-05-4
- Formula: C6H8O4
- Molecular Weight:144.13
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Monoethyl fumarate
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Biological Activity
Monoethyl fumarate (1-6 μg/mL, 6-24 h) modifies the Cys151 site on the KEAP1 protein, modulates the glutathione expression, induces nuclear translocation of NRF2 protein, and the expression of NRF2 target genes[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human spinal cord astrocytes
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Concentration:1-6 μg/mL
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Incubation Time:24 h
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Result:Upregulated the expressions of HMOX1, OSGIN1, NQO1, HMOX1, GCLC and SRXN1.
Chemical Information
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CAS No. 2459-05-4
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Appearance Solid
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Molecular Weight 144.13
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Formula C6H8O4
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Color White to off-white
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SMILES
CCOC(/C=C/C(O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Aging Cell
2026 Apr;25(4):e70462. PMID: 41910356 -
An Acad Bras Cienc
Huanglian Decoction treats Henoch-Schonlein purpura nephritis by inhibiting NF-κB/NLRP3 signaling pathway and reducing renal IgA deposition. [Abstract]2024 Apr 8;96(1):e20220970. PMID: 38597498
Solvent & Solubility
H2O : 100 mg/mL (693.82 mM; Need ultrasonic)
DMSO : 100 mg/mL (693.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (17.35 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (17.35 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Ausama Atwan, et al. Oral Fumaric Acid Esters for Psoriasis. Cochrane Database Syst Rev. 2015 Aug 10;2015(8):CD010497. [Content Brief]
[2]. Brennan MS, et al., Dimethyl fumarate and monoethyl fumarate exhibit differential effects on KEAP1, NRF2 activation, and glutathione depletion in vitro. PLoS One. 2015 Mar 20;10(3):e0120254. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 6.9382 mL | 34.6909 mL | 69.3818 mL | 173.4545 mL |
| 5 mM | 1.3876 mL | 6.9382 mL | 13.8764 mL | 34.6909 mL | |
| 10 mM | 0.6938 mL | 3.4691 mL | 6.9382 mL | 17.3455 mL | |
| 15 mM | 0.4625 mL | 2.3127 mL | 4.6255 mL | 11.5636 mL | |
| 20 mM | 0.3469 mL | 1.7345 mL | 3.4691 mL | 8.6727 mL | |
| 25 mM | 0.2775 mL | 1.3876 mL | 2.7753 mL | 6.9382 mL | |
| 30 mM | 0.2313 mL | 1.1564 mL | 2.3127 mL | 5.7818 mL | |
| 40 mM | 0.1735 mL | 0.8673 mL | 1.7345 mL | 4.3364 mL | |
| 50 mM | 0.1388 mL | 0.6938 mL | 1.3876 mL | 3.4691 mL | |
| 60 mM | 0.1156 mL | 0.5782 mL | 1.1564 mL | 2.8909 mL | |
| 80 mM | 0.0867 mL | 0.4336 mL | 0.8673 mL | 2.1682 mL | |
| 100 mM | 0.0694 mL | 0.3469 mL | 0.6938 mL | 1.7345 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Monoethyl fumarate Related Classifications
HY-W019696 Related Classifications
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