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Cat. No.: HY-164683

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MRP1-IN-1

MRP1-IN-1 (Compound 9h) is a MRP1 inhibitor with an EC₅₀ of 0.90 μM in HeLa-T5 cells.

For research use only. We do not sell to patients.

CAS No.: 246238-55-1
Formula: C₂₈H₂₄ClN₃O₆
Molecular Weight:533.96

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

MRP1-IN-1 Chemical Structure

CAS No.: 246238-55-1

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Biological Activity

Description

MRP1-IN-1 (Compound 9h) is a MRP1 inhibitor with an EC₅₀ of 0.90 μM in HeLa-T5 cells^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	1.8 μM Compound: LY-402913	Inhibition of MRP1-mediated transport of [3H]LTC4 expressed in human HeLa T5 cells by liquid scintillation counting Inhibition of MRP1-mediated transport of [3H]LTC4 expressed in human HeLa T5 cells by liquid scintillation counting	[PMID: 19580319]

Chemical Information

CAS No. 246238-55-1
Molecular Weight 533.96
Formula C₂₈H₂₄ClN₃O₆
SMILES

O=C1C2=C(C)ON=C2C3=C(N1C4=CC=CC(CC(NC5=CC(OC)=C(C(OC)=C5)OC)=O)=C4)C=CC=C3Cl
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Norman BH, et, al. Tricyclic isoxazoles are novel inhibitors of the multidrug resistance protein (MRP1). Bioorg Med Chem Lett. 2002 Mar 25;12(6):883-6. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MRP1-IN-1

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MRP1-IN-1 Related Classifications

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