Mutant IDH1-IN-3
Mutant IDH1-IN-3 (Compound 1) is a selective allosteric inhibitor of mutant isocitrate dehydrogenase 1 (IDH1). Mutant IDH1-IN-3 has an IC50 of 13 nM for R132H IDH1. Mutant IDH1-IN-3 inhibits the production of D-2-hydroxyglutaric acid (2HG) in cells. Mutant IDH1-IN-3 can be used in the study of cancer.
For research use only. We do not sell to patients.
- CAS No.: 1648909-73-2
- Formula: C22H30N4O
- Molecular Weight:366.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
R132H IDH1 13 nM (IC50) |
Chemical Information
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CAS No. 1648909-73-2
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Molecular Weight 366.50
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Formula C22H30N4O
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SMILES
OC1=C(CN2C=CN=C2)C=C(C(C)(C)CC(C)(C)C)C=C1CN3C=CN=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Mutant IDH1-IN-3 Related Classifications
HY-100476 Related Classifications
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