Myokinasib-II
Myokinasib-II is a MLCK1 inhibitor with an IC50 of 4.4 μM. Myokinasib-II induces cell cortex softening, impairs cell migration capacity, induces multinucleation, reduces cell stiffness, alters membrane tether dynamics, decreases actomyosin tension and changes nuclear morphology. Myokinasib-II is a MLCK1 chemical biology probe with a unique structure that does not depolymerize tubulin and maintains cell viability even under high-concentration treatment in fibroblasts.
For research use only. We do not sell to patients.
- Formula: C24H24FN3O4
- Molecular Weight:437.46
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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MLCK1 4.4 μM (IC50) |
Myokinasib-II (10 μM) reduces the fluorescence intensity of pMLC without disrupting actin stress fibers in NIH3T3 mouse embryonic fibroblasts[1].
Myokinasib-II (10 μM; 6-24 h) reduces cortical stiffness and nucleomyosin tension in NIH3T3 cells, inhibits cell migration, and induces multinucleation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 437.46
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Formula C24H24FN3O4
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SMILES
O=C(C1(C(C2=CC=C(F)C=C2C)C([N+]([O-])=O)C3(C)N1)CC4=C3NC5=C4C=CC=C5)OCC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Myokinasib-II Related Classifications
HY-169183 Related Classifications
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